# Michigan Alzheimer's Disease Research Center

> **NIH NIH P30** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $3,075,904

## Abstract

ABSTRACT – OVERALL
Four years ago the Michigan ADRC (MADRC) was established as a new consortium linking the three major
research universities in Michigan: University of Michigan, Michigan State University, and Wayne State
University. Serving the entire state of Michigan, the new MADRC achieved its milestones in wide-ranging
activities and research that emphasized a central theme: to identify, understand and treat the myriad non-β-
amyloid contributions to brain dysfunction and degeneration in Alzheimer’s disease and related dementias
(ADRD). With continued NIA support, the MADRC proposes to maintain this central theme because it captures
the diverse expertise of our dementia scientists, sheds light on ADRD heterogeneity, and reflects the
experience of the racially diverse pool of research participants engaged in MADRC-sponsored studies. To
achieve its objectives, the MADRC has four major aims: 1) Catalyze and perform research of the highest
impact in ADRD; 2) Promote regional efforts to understand, diagnose and treat the full spectrum of dementias
through collaborative scientific and outreach efforts; 3) Provide training and research opportunities for health
care professionals, scientists, and students in ADRD through innovative educational and mentoring programs;
and 4) Collaborate with other ADRCs, the NACC, NCRAD, and other multi-center efforts to lead the field in
developing new diagnostic and therapeutic interventions for these devastating diseases. The integrated efforts
of seven Cores, including new Neuroimaging and Biomarker cores, will support a wide range of basic, clinical,
translational and health disparities research advancing the field toward: improved understanding of disease
mechanisms; more precise disease identification across the dementia spectrum; development of novel
biomarkers; increased knowledge of the basis for health disparities that disproportionately affect Black
Americans; development of non-pharmacological therapies; and the identification and modification of disease
risks. The Research Education Component (REC) will serve as the centerpiece of innovative training
opportunities spanning all the Cores, and a new Leaders Initiative will support and promote a diverse group of
next-generation leaders in dementia research. Benefitting from the outstanding resources of all three
universities and strong multi-institutional support, the MADRC is poised to make new discoveries, educate the
public, and train next-generation leaders as we seek to achieve the milestones set forth in the National
Alzheimer’s Project Act.

## Key facts

- **NIH application ID:** 10473806
- **Project number:** 5P30AG072931-02
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Henry L Paulson
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $3,075,904
- **Award type:** 5
- **Project period:** 2021-09-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10473806

## Citation

> US National Institutes of Health, RePORTER application 10473806, Michigan Alzheimer's Disease Research Center (5P30AG072931-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10473806. Licensed CC0.

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