# Function of Metal Transporter ZIP14 as Regulated by Proinflammatory Stimuli

> **NIH NIH R56** · UNIVERSITY OF FLORIDA · 2021 · $152,412

## Abstract

Abstract For This R56 Project
Guiding Hypothesis: Zinc transport mediated by Zip14 (Slc39a14) influences gene expression in enterocytes that in turn alters intestinal barrier function.
Goal: Evaluate mechanisms of enterocyte-specific Zip14 ablation and replacement zinc supplementation on epigenetic alterations including histone methylation and acetylation, transcription factor activation and lncRNAs and miRNAs that regulate genes in intestinal epithelial cells which influence barrier function.

## Key facts

- **NIH application ID:** 10474233
- **Project number:** 2R56DK094244-10
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** ROBERT J COUSINS
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $152,412
- **Award type:** 2
- **Project period:** 2011-09-23 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10474233

## Citation

> US National Institutes of Health, RePORTER application 10474233, Function of Metal Transporter ZIP14 as Regulated by Proinflammatory Stimuli (2R56DK094244-10). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10474233. Licensed CC0.

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