# Core 3: Biostatistics

> **NIH NIH P50** · SLOAN-KETTERING INST CAN RESEARCH · 2022 · $125,517

## Abstract

ABSTRACT
The role of the Biostatistics Core is to support the investigators of the Leukemia SPORE in their research
efforts, including laboratory experiments, molecular studies, and analysis of clinical trial and correlative data.
Prior to the initiation of all studies, Core staff will consult with SPORE investigators to discuss the underlying
scientific premise and translational goals of the project, to help the investigators select the most efficient and
robust analytical methods, and to estimate sample sizes to ensure adequate power to address study
objectives. In laboratory experiments, Core members will assist in the formulation of the experimental design
and in the analysis and interpretation of the data at the conclusion of the study. For molecular studies using
human tissues, Core members will closely interface with the members of the Genomics Core and will have
primary responsibility for merging molecular and clinical data, and for performing appropriate statistical and
bioinformatics analyses. The members of the Biostatistics Core will also work with SPORE investigators to
format data for publication and assist with deposition of genomic data into public repositories to facilitate
validation of results by external investigators using their own analytical methods. For clinical studies, they will
work with SPORE investigators to help set up effective systems to collect and track all required data. As the
research project (RP) studies proceed, Core staff will review project databases and monitor the quantity and
quality of data collected, and they will suggest modifications to the design and analysis plans as appropriate.
When studies are finished, the Core will conduct correct and efficient data analyses. They will also assist
investigators with the preparation of any necessary graphs and tables, the interpretation of results, the
preparation of presentations and manuscripts, and will consult on the design of subsequent research. If current
statistical methodology does not adequately address a research question, alternative methodologies will be
developed. We believe that this experienced and collaborative Core is well configured to provide the SPORE
with a high level of statistical leadership and support that will enhance the efficiency, quality, and quantitative
rigor of its science.

## Key facts

- **NIH application ID:** 10474272
- **Project number:** 5P50CA254838-02
- **Recipient organization:** SLOAN-KETTERING INST CAN RESEARCH
- **Principal Investigator:** MITHAT GONEN
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $125,517
- **Award type:** 5
- **Project period:** 2021-08-24 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10474272

## Citation

> US National Institutes of Health, RePORTER application 10474272, Core 3: Biostatistics (5P50CA254838-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10474272. Licensed CC0.

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