# WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center

> **NIH NIH U24** · WASHINGTON UNIVERSITY · 2022 · $2,493,199

## Abstract

PROJECT SUMMARY
 The goals of the WashU-Northwestern Genomic Variation and Function Data and Administrative
Coordinating Center (IGVF-DACC) component of the IGVF Consortium are to collect, store, curate, and display
all data, metadata, and analysis tools generated by the IGVF Consortium. The DACC will assist in developing
and disseminating metadata and standards to be adopted by the community at large, approaches for integrative
analysis of a wide range of data types, and visualization and analysis tools to facilitate access and understanding
of complex datasets to non-expert users. Ultimately, the IGVF Consortium will produce tools, analyses, models,
and data that form the catalog of variants and their functional impact. We will develop the DACC into a substantial
service organization allowing scientific research to take full advantage of the IGVF reference catalog or map. To
support the IGVF Consortium, we will establish databases with an application framework to facilitate complex
data loading. We will include detailed experimental descriptions and metadata. We will define and develop
pipelines that connect all Consortium members to the data and create avenues of access that distribute the data
to the greater biological research community. We will establish metadata requirements, controlled vocabularies,
standardized data formats, and quality control metrics for all IGVF data. We will bring together laboratories that
generate complex data types via experimental assays with laboratories that integrate these data using
computational tools to define the effects of genomic variation on genome function and how these effects shape
phenotypes. By creating structures and data flow pipelines for the verification and validation of all data and
providing processes for the documentation of metadata, the DACC will enhance the IGVF data production. The
DACC will also coordinate integrative data analysis by creating and adapting analysis pipelines and developing
advanced Genome Browser functions for the visual integration of IGVF data. Also, we will make the IGVF Web
Portal that will be the primary entry point to the wealth of experimental data and computational analyses. The
Portal will integrate these data resources and make them available via enhanced search and browsing
capabilities. Finally, the DACC will provide documentation, training, and outreach via many media, including
written documentation, video tutorials, online books, webinars, and meeting workshops and presentations.

## Key facts

- **NIH application ID:** 10474397
- **Project number:** 5U24HG012070-02
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Ting Wang
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $2,493,199
- **Award type:** 5
- **Project period:** 2021-08-24 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10474397

## Citation

> US National Institutes of Health, RePORTER application 10474397, WashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating Center (5U24HG012070-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10474397. Licensed CC0.

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