# Neuropathology Core

> **NIH NIH P30** · CLEVELAND CLINIC LERNER COM-CWRU · 2022 · $370,315

## Abstract

PROJECT SUMMARY
 The goals of the Neuropathology Core (NPC) are to perform standardized postmortem
neuropathological evaluation, and classification of subjects recruited by the Cleveland Alzheimer's Disease
Center (CADRC), and to collect, store, and analyze fixed and frozen autopsy materials for use in future
research. Drs. Cohen and Appleby, who bring expertise in the areas of molecular pathology and
clinicopathologic correlation of neurodegenerative disease, will lead the NPC.
 To support AD research projects, the NPC will perform all tissue processing for histology and
freezing, and immunohistochemical investigations of Alzheimer's disease (AD) and related dementias
(ADRD). The NPC will also characterize archival tissue of AD cases in the brain banks at participating
sites, to more rapidly make available tissues for investigation.
 The goal of the CADRC NPC is to obtain, characterize, and maintain neuropathologic specimens
from subjects affected by AD and related dementias (ADRD). With over two decades of experience in
conducting autopsies from across the country and maintaining neuropathologic tissue, the CADRC NPC will
be maintained via infrastructure that has been proven through the work of the National Prion Disease
Pathology Surveillance Center (NPSPSC) (Specific Aim 1). Experts in the field of neurodegeneration (Drs.
Cohen and Leverenz) will characterize neuropathologic specimens according to accepted standardized criteria
(Specific Aim 2). The CADRC will have access to and will help characterize a unique cohort of ADRD samples
obtained through the NPDPSC (Specific Aim 3). Finally, the NPC will foster the next generation of AD
researchers by training and mentoring junior faculty in neuropathology and current concepts of basic
neuroscience of age-related neurodegenerative diseases (Specific Aim 4). We anticipate the CADRC NPC to
provide essential infrastructure to greatly facilitate and integrate independent research on ADRD that are
currently active at a local, national, and international level.

## Key facts

- **NIH application ID:** 10474601
- **Project number:** 5P30AG072959-02
- **Recipient organization:** CLEVELAND CLINIC LERNER COM-CWRU
- **Principal Investigator:** Mark Cohen
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $370,315
- **Award type:** 5
- **Project period:** 2021-09-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10474601

## Citation

> US National Institutes of Health, RePORTER application 10474601, Neuropathology Core (5P30AG072959-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10474601. Licensed CC0.

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