# Core D: Drug Development

> **NIH NIH P01** · UNIVERSITY OF ARIZONA · 2022 · $104,734

## Abstract

ABSTRACT 
Core D (Myrdal) Drug Development 
The Drug Development Core will serve the individual Projects and the Program Project as a whole by providing 
necessary services and a unique combination of expertise in pharmacology/toxicology, pharmaceutics, 
manufacturing and regulatory affairs that enable the clinical translation of topical agents. This objective will be 
accomplished by the following Specific Aims: 1) To prepare stable formulations of promising new agents that 
can be safely and effectively delivered to the epidermis following topical application through a) preformulation 
activities, b) formulation development and c) determination of percutaneous absorption and dermal toxicity; and 
2) Facilitate the translation of agents into the clinic by a) performing preclinical toxicology studies consistent with 
GLP practices and monitoring the stability of the formulation lots used in these studies, and b) coordinating and 
preparing New Drug (IND) applications for FDA approval and supervising production and distribution of clinical 
grade supply for human trials in Project 3. Implementation of these aims will allow Project Leaders the ability to 
circumvent problems with epidermal delivery which may hinder development of otherwise promising topical 
agents, and optimize the crucial selection criteria for advancement of new agents to clinical testing. This will 
greatly enhance the ability to translate basic science discoveries into new skin cancer chemopreventive drugs.

## Key facts

- **NIH application ID:** 10475155
- **Project number:** 5P01CA229112-04
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Heidi M. Mansour
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $104,734
- **Award type:** 5
- **Project period:** 2019-09-10 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10475155

## Citation

> US National Institutes of Health, RePORTER application 10475155, Core D: Drug Development (5P01CA229112-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10475155. Licensed CC0.

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