# Genetic, Biomarker and Biospecimen Core

> **NIH NIH P30** · INDIANA UNIVERSITY INDIANAPOLIS · 2022 · $355,516

## Abstract

Project Summary – Genetics, Biomarker, and Biospecimen Core (GBBC)
The Indiana Alzheimer’s Disease Research Center (IADRC) has a strong history of innovative
research in molecular and imaging genomics and will continue to focus on the role of genetics
and other types of biomarkers as predictors of clinical trajectories among the broader group of
individuals with Alzheimer’s disease (AD) and other dementias, as well as those in preclinical
and prodromal stages, such as subjective cognitive decline (SCI) and mild cognitive impairment
(MCI). The Genetics, Biomarker and Biospecimen Core (GBBC) plays a central role in
supporting this overall focus through the collection of uniform biospecimens, coordination of
genetic data and generation of blood-based biomarkers. The GBBC also supports multiple
national efforts through the broad sharing of specimens and data.
The GBBC leverages the unique patient populations and genomics resources at Indiana
University School of Medicine to support each Core as well as the overall goals of the IADRC.
The GBBC fosters new research directions through the common banking of samples from
diverse research groups. These samples are then available to address research questions that
are central to the interests of the IADRC. In addition, these samples are available for
collaborative studies, thereby enhancing the power of all ADRC studies focused on disease
susceptibility, onset and progression.
In this application, the GBBC will expand its scope to also support functional studies through the
targeted development of induced pluripotent stem cells (iPSCs). The GBBC will leverage both
the IUSM-JAX-Pitt MODEL-AD Center, whose goal is to develop, characterize and test
therapeutic strategies in mouse models of AD and the IUSM-Purdue TREAT AD Center, whose
goal is to integrate sophisticated capabilities for early drug discovery, to contribute to a broader
study of AD target hypotheses (beyond Aβ) to generate new classes of potential therapeutics.
The IADRC GBBC proposes the following specific aims:
 1. Obtain longitudinal biospecimen samples from all subjects seen in the Clinical Core and
 support local and national research studies.
 2. Obtain biomarker data to support ongoing studies of cognitive impairment and dementia.
 3. Establish iPSCs from select IADRC participants to support local research studies.
 4. Provide education in the areas of genetics and biomarkers.

## Key facts

- **NIH application ID:** 10475194
- **Project number:** 5P30AG072976-02
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** TATIANA M. FOROUD
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $355,516
- **Award type:** 5
- **Project period:** 2021-09-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10475194

## Citation

> US National Institutes of Health, RePORTER application 10475194, Genetic, Biomarker and Biospecimen Core (5P30AG072976-02). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10475194. Licensed CC0.

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