The overarching goal of the Resource Core is to make high quality data and expertise accessible to a broad community of investigators interested in musculoskeletal research. To that end, we have two main aims: 1) to provide access to data needed for musculoskeletal research, as well as the methodologic expertise and tools to address the research questions at hand, and 2) to ensure that the data, services, and research products maintained by the Resource Core are used by a broad range of investigators and the NIAMS research community. The Resource Core supports access to a number of existing robust, ready-to-use musculoskeletal research databases. It also will facilitate access to databases not specifically designed for musculoskeletal research, to be harnessed for musculoskeletal research, such as MarketScan Claims data and Centers for Medicare and Medicaid services data (CMS). These datasets provide a wide variety of data relevant to the NIAMS mission of musculoskeletal research including imaging data, clinical data, and patient reported outcomes. Further, the Resource Core will conduct analyses within the Center using these databases to provide a pathway for CCCR investigators to conduct replication or external validation studies. The Resource Core will actively promote the novel methodologic and biostatistical tools and “products” developed by the Methodologic Core and Image Processing Group as well. The Resource Core will continue to (1) actively engage researcher and clinician stakeholders to promote the use of data resources and services, and (2) disseminate the research products developed by the Methodologic Core through channels that reach researcher and clinician stakeholders. We will track the Core’s success using metrics that reflect the use of Resource Core data, services, and research products, including the number of grants submitted and funded, publications, and current projects. The Resource Core will also contribute to an Enrichment Program, led by the Administrative Core, that includes Pilot and Feasibility awards for researchers likely to be NIAMS-funded in the future, scientific webinars related to the Center’s resources and focus areas, and an annual Visiting Scientist Program organized by the Methodologic Core.