# Molecular & Cellular Analysis Core

> **NIH NIH P30** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 · $160,933

## Abstract

UAB Center Core for Vision Science - Molecular & Cellular Analysis Core
Project/Summary Abstract
The Molecular & Cellular Analysis Core was approved as a molecular biology/histology core and has been an
active and critical core for many Core participants for more than 15 years. Core participants in the current cycle
have demonstrated outstanding productivity publishing 178 papers (an 11% increase over the previous cycle).
For the proposed funding cycle, of the 14 moderate or extensive use Core participants, 12 are NEI R01-funded
(86%) and the other two are actively seeking new NEI R01-funding or have other NEI support. Three of the
four limited use Core participants proposed have NEI R01-funding and the other one has funding from other
vision support sources. The core has continued to evolve to meet user needs warranting several core
enhancements. Major institutional support has allowed the purchase of new equipment or the upgrade of some
of the key Core equipment to help meet user needs by providing the most up to date equipment. The focus for
this cycle was to enhance the capabilities of microscopic analysis through major update of a wide-field
microscope and addition of an advanced analysis software suite. The Core encompasses protein and nucleic
acid analysis, histology, and now advanced microscopy imaging and analysis. Dr. Pittler, the Core Director is
an expert in cell and molecular biology, and biochemistry focusing on animal models of retinal degeneration
and will continue as the Core Director. Dr. Marina Gorbatyuk, an expert in AAV technology and the study of the
unfolded protein response in animal models will continue as the Associate Director to assist with Core
governance and metrics analysis. In addition to having advanced equipment for analysis, the Core has a highly
educated, well-trained PhD scientist, Dr. Jose Luis Roig as the Laboratory Director. His broad knowledge and
experience base and overall scientific skill is a major asset. The Core equipment is primarily housed in
dedicated space in close proximity to most users and is accessible 24/7. Conflicts in usage scheduling is
minimized through a comprehensive online scheduler for all major equipment. Outstanding institutional support
has been critical in many ways: (1) to provide the facilities that house Core equipment and an office for the
laboratory director, (2) to maintain the equipment, (3) and to obtain new equipment to increase core capability.
Core usage is carefully monitored to ensure priority of use among Core participants as follows: NEI R01-
funded participants have first priority for use (1), followed by participants with NIH new investigator status that
are actively seeking an NEI R01 (2), then by participants that are collaborating as key personnel on an NEI
R01 and actively seeking lead PI NEI R01 support (3), and lastly by participants that have recently in the last
three years been NEI R01-funded and are actively seeking new NEI R01 support (4).

## Key facts

- **NIH application ID:** 10476367
- **Project number:** 5P30EY003039-42
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** STEVEN J PITTLER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $160,933
- **Award type:** 5
- **Project period:** 1997-08-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10476367

## Citation

> US National Institutes of Health, RePORTER application 10476367, Molecular & Cellular Analysis Core (5P30EY003039-42). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10476367. Licensed CC0.

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