# Impact of the COVID-19 pandemic on patient outcomes, telehealth care delivery, and treatment for unhealthy alcohol use in vulnerable patients with advanced liver disease across two healthcare systems

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $4,974

## Abstract

PROJECT SUMMARY (SUPPLEMENT)
This administrative supplement application is to request additional funds in order to comply with
NOT-AA-19-020, “Notice of NIAAA Data-Sharing Policy for Human Subjects Grants Research
Funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).” As stated in the
Notice, the NIAAA requires NIAAA-funded studies that include human subjects to submit de-
identified data into the NIAAADA, a NIAAA data repository hosted and managed by the NIMH
Data Archive (NDA), in order to increase value to research through widespread data sharing.
The goal of this supplement request is to ensure budgetary support to fulfill the requirements of
the NDA. The data to be submitted through this supplement will include parent study data
relevant to the care of patients with advanced chronic liver disease (CLD) during the COVID-19
pandemic within hepatology practices in two health systems, a public safety net system and
Veterans Affairs healthcare systems. In the parent study we will: 1) evaluate the impact of the
COVID-19 pandemic on clinical outcomes of vulnerable patients with advanced CLD receiving
care in hepatology practices, in a natural experiment; 2) Evaluate patient-reported experiences
with use of telemedicine in response to the pandemic to deliver hepatology specialty care in
those with advanced CLD; and 3) Conduct a randomized controlled trial evaluating the efficacy
and feasibility of a stepped alcohol treatment using telemedicine on unhealthy alcohol use in
patients with alcohol-related CLD receiving care in hepatology practices, compared with usual
care. Data from the completion of these study objectives will be included in the data archiving to
be supported by this administrative supplement.

## Key facts

- **NIH application ID:** 10476764
- **Project number:** 3R01AA029312-01S1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Mandana Khalili
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $4,974
- **Award type:** 3
- **Project period:** 2021-09-21 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10476764

## Citation

> US National Institutes of Health, RePORTER application 10476764, Impact of the COVID-19 pandemic on patient outcomes, telehealth care delivery, and treatment for unhealthy alcohol use in vulnerable patients with advanced liver disease across two healthcare systems (3R01AA029312-01S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10476764. Licensed CC0.

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