# Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of Epilepsy

> **NIH NIH UG3** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $2,500,069

## Abstract

ABSTRACT
 The goal of this project is to significantly advance the field of acute and semichronic epilepsy monitoring
using novel, high-resolution electrocorticography (ECoG) record/stimulate grids (4096/256 channels,
respectively) and stereoelectroencephalography (sEEG) depth electrodes (120/8 micro/macro) with full wireless
data and power transfer. This project builds on our previous success in conducting the first-ever human trials for
acute mapping of eloquent brain tissue with multi-thousand channel microelectrode grids. The proposed system
encompasses multiple transformative technological approaches, including: (1) leveraging advanced thin-film
microfabrication on 8” diameter substrates, thus permitting long integrated connectorization from thousands of
channels; (2) exploiting a newly developed platinum nanorod (PtNR) microelectrode technology with excellent
low impedance, high charge-injection-capacity (4.4mC/cm2), stability, and biocompatibility; and (3) using a thin
(~10μm) parylene C substrate that is compliant to brain movements, conformal to brain curvature, and
transparent, permitting easier visualization of brain anatomy during the acute mapping. Further, (4) the grids
developed for this project are modular and can be trimmed to fit different sizes of craniotomies, and (5) this
system offers a new generation of minimally invasive sEEG electrodes with easily reconfigurable microcontact
distribution in different regions of the brain Our proposed system also (6) employs state-of-the-art acquisition
electronics with a miniaturized 1024ch neural interface system-on-chip and radio transmission of data and power,
enabling fully wireless monitoring that eliminates wire externalization, and (7) deploys multi-screen and multi-
window visualization of the whole repertoire of electrophysiological activity, with the option to display and interpret
signals in standard fashion.
 Our goal is to demonstrate in the semichronic clinical setting a high-definition display of traditional and
emerging clinical biomarkers for epilepsy monitoring and treatment. To achieve this goal, we will pursue in Aim
1 regulatory input from the FDA and scale our grids under good quality laboratory practices (GLP), and perform
benchtop testing and hardware and software development under a quality management system. In Aim 2, we
will perform semichronic animal testing under GLP to demonstrate safety, tolerability, and efficacy of the new
epilepsy-monitoring system. In Aim 3, we will will perform pre-clinical and human intraoperative recordings with
appropriate IRB authorization. We will pursue FDA clearance for semichronic implants in Aim 4, and transition
Aim 5 to semichronic epilepsy monitoring in patients with intractable epilepsy.
 The methods employed in device and system development, surgical approaches, electrophysiology, and data
analysis will not only advance functional and epilepsy monitoring but will also have significant implications for
numerous applications...

## Key facts

- **NIH application ID:** 10477274
- **Project number:** 5UG3NS123723-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Shadi Dayeh
- **Activity code:** UG3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $2,500,069
- **Award type:** 5
- **Project period:** 2021-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10477274

## Citation

> US National Institutes of Health, RePORTER application 10477274, Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of Epilepsy (5UG3NS123723-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10477274. Licensed CC0.

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