SUMMARY, Administrative Core The goal of the Administrative Core of the Colorado Head and Neck Cancer (HNC) SPORE is to facilitate innovative translational science that will accelerate the application of new discoveries to the clinic for HNC patients. The primary objective of the Administrative Core is to provide scientific leadership, administrative services and financial oversight, and to function as a communication hub for all SPORE-related activities. The Administrative Core will support investigators and personnel in projects 1-3, the Biospecimen/Pathology Core, the Developmental Research Program (DRP), the Career Enhancement Program (CEP), and the Tissue Use Committee. The Administrative Core personnel interact with the patient advocates to coordinate their activities and integrate their participation in SPORE activities and provides support to the External and Internal Advisory Boards as well as visiting scientists, fellows, and all collaborating investigators from academia and industry. The Administrative Core provides each of these groups with centralized organization and support for their activities, and helps each group stay informed about activities, meetings, opportunities and other information pertinent to the SPORE. The Administrative Core will be responsible for communication with NCI and will provide support for all collaborations. Continuity of support provided by the staff will result in efficient and effective administration for the CO HNC SPORE.