# Colorado HNC SPORE Data Sciences Core

> **NIH NIH P50** · UNIVERSITY OF COLORADO DENVER · 2022 · $134,588

## Abstract

SUMMARY, Data Science Core
The University of Colorado Head and Neck Cancer (CO HNC) SPORE Data Science Core (DSC) provides
services for biostatistics, informatics, bioinformatics, and other data science related analyses. The DSC staff is
comprised of five Ph.D. and one Master’s level researchers who collectively offer substantial expertise in clinical
trial design and analysis; statistical genetics, multi-omics data analysis; software development; predictive
modeling; and cancer-focused bioinformatics. The core includes a comprehensive team of biostatisticians,
bioinformaticians, and an epidemiologist, that form a hub of researchers with the common denominator of being
engaged in HNC research through exisiting collaborations. The DSC has the overarching objective to build a
community of practice related to HNC data science. All staff are operationally managed and overseen by the
DSC Director, Dexiang Gao Ph.D, and like all faculty in the CO HNC SPORE the DSC faculty are members of
the University of Colorado Cancer Center (UCCC), specifically the Biostatistical and Bioinformatics shared
resource (BBSR). The BBSR has a long-standing history of collaboration with the Head and Neck research team
over the past 10 years. Faculty biostatisticians and bioinformaticians are engaged in the development of novel
methods and tools that enhance the HNC SPORE. Since 2015, faculty within the DSC published ~20 peer-
reviewed manuscripts (with an additional 5 in preparation) and collaborated on 9 peer-reviewed extramural R01
grants with HNC SPORE investigators, 4 of which are active awards. By harnessing these established
collaborations, the DSC can effectively and efficiently support CO HNC SPORE projects. Integrating personnel
within a Core to support all SPORE programs will maximize available resources to increase the DSC’s scientific
impact. Specifically, the DSC will provide assistance with research hypotheses formulation, clinical trial designs,
sample size determination, analytical and database design, data collection, analyses, management and storage.
This support will continue through management and coordination of accumulating research and clinical data
analyses, assistance with manuscript preparation and clinical trial reports in relation to key quantitative findings
and rigorous scientific conclusions. Thus, the DSC will play a critical role in clinical trials, as well as basic science
and translational studies.

## Key facts

- **NIH application ID:** 10477445
- **Project number:** 5P50CA261605-02
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Dexiang Gao
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $134,588
- **Award type:** 5
- **Project period:** 2021-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10477445

## Citation

> US National Institutes of Health, RePORTER application 10477445, Colorado HNC SPORE Data Sciences Core (5P50CA261605-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10477445. Licensed CC0.

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