# Core C: Vulnerable Populations Core

> **NIH NIH P20** · MIRIAM HOSPITAL · 2022 · $216,130

## Abstract

PROJECT SUMMARY / ABSTRACT 
The COBRE for Stress, Trauma, and Resilience (STAR) will establish a transformative, transdisciplinary 
Miriam Hospital research center focused on the biobehavioral mechanisms through which childhood stress, 
trauma, and adversity impact health outcomes across development. Childhood adversity is a major risk factor 
for physical and mental health problems across the lifespan, yet those with adverse exposures are highly likely 
to be underserved due to socioeconomic position. Children and adults from disadvantaged backgrounds, 
including racial and ethnic minorities, individuals living in poverty, and sexual minority and gender diverse 
populations are at substantially heightened risk of exposure to adversity. Further, although disadvantaged 
communities are most likely to experience adversity and trauma, they are often difficult to reach and engage in 
research as a result of societal discrimination, medical mistrust, marginalization, stigma, and economic and 
structural factors. Specialized infrastructure to address the practical, ethical, and clinical issues in research 
with vulnerable and underserved populations is critical for long-term success of the STAR COBRE. The 
Human Subjects and Vulnerable Populations (VP) Core will support the overall goals of the STAR 
COBRE by building critical infrastructure to support clinically significant and highly innovative 
research with vulnerable children and adults with stress and trauma histories. In addition, because all 
three proposed research projects in this COBRE include data and biospecimens from human subjects, the VP 
Core will serve as a recommended hub for documentation and training related to human subjects’ 
protection for all components of the COBRE (PAR-19-313). The VP Core will provide resources and 
support targeted to developing capacity to successfully recruit and retain difficult to reach populations, 
while maintaining to standards in the ethical conduct of research with children and adults with stress and 
trauma histories. The VP Core will also provide support to enhance existing and build new community 
partnerships, and to increase competence of COBRE faculty and staff regarding issues of diversity, equity, 
and inclusion. The VP Core will be essential to the overall success of the STAR COBRE by providing critical 
expertise, services, and infrastructure to support clinically significant and highly innovative research with 
vulnerable children and adults with stress and trauma histories.

## Key facts

- **NIH application ID:** 10478814
- **Project number:** 5P20GM139767-02
- **Recipient organization:** MIRIAM HOSPITAL
- **Principal Investigator:** Stephanie Hart Parade
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $216,130
- **Award type:** 5
- **Project period:** 2021-09-15 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10478814

## Citation

> US National Institutes of Health, RePORTER application 10478814, Core C: Vulnerable Populations Core (5P20GM139767-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10478814. Licensed CC0.

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