# Pathology Core

> **NIH NIH U54** · CASE WESTERN RESERVE UNIVERSITY · 2022 · $64,650

## Abstract

ABSTRACT – Path Core
The Pathology Core will provide services to this proposal essential to the success of the projects.
The Core will leverage existing technologies and infrastructure in Uganda and Tanzania as well
as CWRU to provide reliable diagnoses of prospective project enrollees. The Pathology Core
facilities include state of the art slide scanners which have been installed at the two African
Pathology coordinating centers. The scanners are part of a large multi-institutional continent-wide
program organized by the American Pathology of Clinical Pathology to improve surgical pathology
diagnostic standards in Africa through a program of targeted infrastructure development. This
program has enabled both teaching for faculty and residents in pathology diagnostics as well as
facilitating pathology consultations across the globe. The slide scanning system and software are
robust and user friendly. The program has been extremely successful and has been extensively
implemented – linking multiple pathology departments in Africa to departments throughout the US
and Europe. The design of the Core will facilitate rapid turnaround of pathology diagnoses through
consensus. The two African center Pathology Leaders have extensive experience in the
presentation of a host of non-cancerous lesions of the lung. This experience compliments that of
Dr Willis, the Pathology Core Leader at CWRU, with his extensive experience in diagnostic
oncology. The CWRU Pathology Core Center also has extensive experience in digital slide
imaging management and translational research having extensive engagement with the CWRU
Center for Computational Imaging & Personalized Diagnostics. Central to the mission of the core
is standardization of diagnoses through teaching and cross center engagement. This will include
cross visits by Drs Willis and Lukande. The core will also engage in important technology transfer
of the technique of immunohistochemistry to both main sites in Africa. Immunohistochemistry is
fundamental to modern diagnostic pathology and a pillar of diagnostic accuracy especially in
oncology. Techniques to be introduced are designed to be used in low / middle resource centers
and are flexible so that incremental additions to immunohistochemical panels can be performed
with only minimal expenditures. The primary objective of the Core is to provide a resource that
contributes significantly to the translational goals and endpoints of the individual projects, to
facilitate cooperation between the three sites and to identify areas of potential further expansion
of oncology–related translational research.

## Key facts

- **NIH application ID:** 10478906
- **Project number:** 5U54CA254566-03
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** JOSEPH EDWARD WILLIS
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $64,650
- **Award type:** 5
- **Project period:** 2020-09-21 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10478906

## Citation

> US National Institutes of Health, RePORTER application 10478906, Pathology Core (5U54CA254566-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10478906. Licensed CC0.

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