Project Summary: Administrative Core The Administrative Core will support an environment of research excellence, scientific innovation, and transdisciplinary scholarship within the Washington University Participant Engagement and Cancer Genomic Sequencing (WU-PE-CGS) Center and among other members of the NCI PE-CGS network of research centers and the coordinating center. The Administrative Core will implement a matrix-style administrative structure to foster excellence in management and communication. Leaders and co-leaders of the three working units in the Center will form the Leadership Committee, which (together with patient advocates) will use a collaborative process to engage and maintain the creativity and leadership of the significant individual and team expertise involved in the Center. The goal of the Administrative Core is to provide the structure for effective and efficient operation and maintenance of the WU-PE-CGS center in compliance with NIH and University guidelines, while leveraging innovative opportunities to advance the field of participant engagement and cancer genomics. The Core will support the overall mission of the WU-PE-CGS through the following aims: (1) Organize the operational structure and scientific leadership for all WU-PE-CGS components and provide oversight to maximize efficiency, effectiveness, and accountability; (2) Build participant engagement for underserved/understudied populations to engage in network-driven collaborative studies via outreach among other Centers in the network and collaboration with patient advocacy groups; (3) Provide scientific leadership in minority and underserved participant engagement and in genome sequencing among other scientists in the network; (4) Evaluate all WU-PE-CGS activities and provide feedback to refine ongoing activities; (5) Establish a timeline and milestones to monitor progress and coordinate efforts. The administrative core will position the WU-PE-CGS to optimize the innovation, pace, and impact of participant engagement research and genomic characterization of rare, understudied cancers. The WU-PE-CGS investigators have substantial expertise and proven track records in conducting collaborative, transdisciplinary science, including research and programs in cancer control, genome sequencing, dissemination of findings to other stakeholders, and translating results for practitioners working in multiple settings. We are uniquely situated to provide scientific leadership to connect and expand a network of cancer-focused participant engagement researchers; support innovation; and enhance capacity for genome sequencing of rare and understudied cancers and directly interact with patient advocacy groups and patients for return of results and ongoing participant engagement. The Administrative Core is a critical element of the overall scientific program and infrastructure for the Center and provides a strong foundation for scholarly excellence, research synergy and efficiency, a...