Scientific Transparency: Project Summary We introduce in this competing renewal the Scientific Transparency Core Module (STCM). This module places the activities of the prior Image Analysis Core Module within a next-generation data curation framework, to bring reproducible and shareable data analysis to VRC investigators. The STCM supports scientific rigor and reproducibility in image analysis for VRC investigators, and provides support from the inception of an innovative analysis approach, to its realization in code, to its application within a reproducible pipeline. Module personnel support the development of innovative analysis tools. This core element of support continues from the Image Analysis Core Module, which has been heavily used during the current funding cycle. We aim to create automated, open-source analysis algorithms that provide reproducible results. Module personnel will also support data curation and analysis pipelines. This module function is based around the commercial Flywheel platform (http://flywheel.io). Brain imaging data obtained by Participating Investigators are already being stored on this system; the STCM will underwrite the costs of placing retinal imaging data on this platform. Module personnel will further assist investigators in placing analysis code within analysis “gears” that operate on data stored in Flywheel. These are software containers that allow open-source analysis code to be executed, without external dependencies, on virtually any computer hardware or operating system. These components create documented, reproducible analysis pipelines that may be shared between VRC investigators and with the larger vision science community.