# Core 3: Assessment and Analysis Shared Resource Core

> **NIH NIH P01** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2022 · $1,019,647

## Abstract

The primary objective of the AMPLIFI Assessment and Analysis (AA) Shared Resource Core (SRC) is to
support the scientific objectives of all AMPLIFI projects and SRCs through data and biospecimen collection,
data management, and statistical and cost-effectiveness analysis. The AA SRC will work in collaboration with
and assist the Recruitment and Retention (RR) and Adaptation, Dissemination, and Implementation (ADI) and
the Administration (ADMIN) SRCs, and leverage exceptional resources at the University of Alabama at
Birmingham. The AA SRC's specific aims are: (1) To implement the AMPLIFI study design. The AA SRC
will randomize 652 survivors to the AMPLIFI study arms using block randomization; (2) To facilitate AMPLIFI
data collection, entry and management. The AA SRC will enter or download, manage, clean, and link all
AMPLIFI data obtained from cancer registries, screening and recruitment process, participants' assessments,
and laboratories. A REDCap system will be set up to track data collection materials sent and received.
Participants' assessments will consist of self-administered questionnaires, phone surveys, home visits (which
include blood and urine sample collection) and accelerometer monitoring. Home visits will be conducted by
Examination Management Services Inc. (EMSI), a company with trained nurses used in previous research
studies. The AA SRC will process, prepare for statistical analysis, and store data from AMPLIFI projects and
ADI and RR SRCs; (3) To plan and conduct statistical analyses for AMPLIFI Projects and Cores. The AA
SRC provides expert statistical and methodological consultation to project investigators and SRC leaders by
planning and conducting statistical analyses in support of AMPLIFI projects, and additional analyses for the RR
and ADI SRCs. This will include testing the efficacy of the AMPLIFI interventions on the primary outcomes,
exploring the interventions' impact on secondary outcomes (including quality of life, physical functioning and
performance, body composition, and biomarkers of inflammation, immune function, and successful aging),
conducting mediator/moderator analyses to ascertain the constructs by which the intervention exerts its effects
and the key survivor characteristics that influence intervention efficacy; and (4) To plan and conduct cost-
effectiveness analyses of the AMPLIFI interventions. The AA SRC will assess if the tested interventions
are economically attractive, i.e., assess how interventions' benefits in terms of quality of life gains compare
with their net cost (implementation costs – savings in health care costs, if any). Attainment of these aims will
contribute to the wider dissemination of the tested interventions by demonstrating their efficacy and cost-
effectiveness, the mechanisms by which they work to impact lifestyle behaviors, and in whom they work best.
The outstanding AA SRC team has decades of experience in implementing study designs, performing data
collection and managemen...

## Key facts

- **NIH application ID:** 10480010
- **Project number:** 5P01CA229997-05
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** MARIA PISU
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,019,647
- **Award type:** 5
- **Project period:** 2018-09-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10480010

## Citation

> US National Institutes of Health, RePORTER application 10480010, Core 3: Assessment and Analysis Shared Resource Core (5P01CA229997-05). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10480010. Licensed CC0.

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