PROJECT SUMMARY - ABSTRACT We will design a fully implantable, wireless, battery-free, Mechano-Acoustic (MA) device that allows for multi- parameter physiological data acquisition from freely moving small animal models, via use of high bandwidth triaxial accelerometers. The proposed technology records relevant vital sign information such as the heart and respiration rate and temperature, and other general features about the animal that include locomotion and body orientation. Each of these features are determined in parallel from subtle motions detected with this platform using the most advanced inertial measurement unit (IMU) technology and transmitted wirelessly and analyzed in real-time using Bluetooth Low Energy (BLE) 5.2 to an external reader system – all isolated to individual subjects within experimental contexts spanning single to multi-animal behaviors. This approach allows other experimental approaches (video tracking, neural recording, closed-loop optogenetics, etc.) to be directly coupled to the recorded physiological data. Integration of a BLE 5.2 reading board into the existing NeuroLux Power Distribution Control (PDC) box will enable simultaneous use with other devices in NeuroLux’s product portfolio, including fully implantable optogenetic devices and wireless drug-delivery systems that are currently in widespread use across various parts of the neuroscience community. By delivering both power and data wirelessly, and by entirely eliminating all external fixtures and physical tethers on the animal, the proposed technology enables chronic physiological recordings in three-dimensional naturalistic environments, from isolated individuals or social groups, in ways that are fundamentally impossible with conventional hardware infrastructure. This low-cost manufacturable system is fully compatible with the NeuroLux radio frequency wireless electronic platform and control software, allowing us to leverage the strengths of an existing commercial platform currently in use in >150 laboratories worldwide to further advance neuroscience research capabilities.