# Optimizing Care Delivery to Support Reengagement in PLWH Returning to HIV Care after Treatment Lapses in Zambia

> **NIH NIH R34** · WASHINGTON UNIVERSITY · 2022 · $211,721

## Abstract

ABSTRACT
Sustained retention in HIV care is critical for viral suppression, but people living with HIV (PLWH) frequently
transition in and out of care over time, putting them at high risk for ongoing viremia and drug resistance. Even
when PLWH return to care after loss to follow-up (LTFU), rates of becoming LTFU again in the future are very
high. Our preliminary data from Zambia suggests that 30% become LTFU again within 6 months, and that 50%
of those who are currently LTFU have previously cycled in and out of care. The time of reengagement in care is
thus a critical period to intervene in this high-risk population, and strategies to improve post-return care delivery
are urgently needed to break ongoing cycles of disengagement. After returning to care, PLWH often report being
scolded, health care workers (HCW) delay ART re-initiation due to adherence concerns and do not consistently
monitor virologic response, and PLWH likely still experience the life situations (e.g., competing obligations, travel
away from home, or psychosocial factors) that led to their initial LTFU. Strategies to 1) target HCW behaviors
(i.e., welcoming returning patients, prompt ART re-initiation) using implementation strategies such as practice
facilitation and audit and feedback and 2) offer PLWH support services tailored to their initial reasons for LTFU
(e.g., extended refills, transfer coordination, peer-navigation) may be promising. To be successful, however, we
need to understand how to effectively implement these approaches into existing care, including 1) how to engage
HCWs in attitude- and behavior-change strategies, 2) what support services to prioritize for different barriers,
and 3) how to integrate activities into existing workflows. This R34 proposal will build the necessary foundation
for implementing a multicomponent reengagement strategy to support sustained reengagement after returning
to HIV care. In Aim 1a, we assess patient and HCW needs and preferences for reengagement strategies with
patient semi-structured interviews (n=20) and focus group discussions with HCWs and clinic leadership (4 FGDs,
n=8-10 each). In Aim 1b, we conduct discrete choice experiments (200 PLWH, 100 HCWs) to quantify relative
preferences for the contents and attributes for our reengagement strategy. In Aim 2, we undertake a human-
centered design process that engages key stakeholders (PLWH, HCWs, clinic leadership, Ministry of Health) in
co-developing the content and features of a multicomponent reengagement strategy focused on 1) improving
the patient reengagement experience, 2) optimizing ART re-initiation and viral load monitoring post-return, and
3) providing tailored services that target individuals’ specific reasons for LTFU. In Aim 3, we will pilot the
developed strategy at one urban and one rural clinic in Lusaka, Zambia. We will use a mixed-methods approach
to assess the implementation (e.g., acceptability, appropriateness), service delivery (e.g., time to ART re-
initia...

## Key facts

- **NIH application ID:** 10484440
- **Project number:** 1R34MH129219-01A1
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Aaloke Mody
- **Activity code:** R34 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $211,721
- **Award type:** 1
- **Project period:** 2022-08-10 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10484440

## Citation

> US National Institutes of Health, RePORTER application 10484440, Optimizing Care Delivery to Support Reengagement in PLWH Returning to HIV Care after Treatment Lapses in Zambia (1R34MH129219-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10484440. Licensed CC0.

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