# Multi-modality Test for improving precision of TBI diagnosis in the elderly.

> **NIH NIH R44** · BRAINBOX SOLUTIONS, INC. · 2022 · $471,835

## Abstract

Project Summary/Abstract
Incidence, hospitalization, and mortality for traumatic brain injuries (TBIs) have greatly increased
in the past decade, even more so for the expanding geriatric population. Despite this, current
diagnostic and prognostic tools for TBI remain wholly inadequate. With this application, we
propose to test and optimize the performance of the BRAINBox TBI Test system, which has
received Breakthrough Designation from the FDA as a first in kind device providing both diagnosis
and prognosis of future symptoms. This test system can rapidly detect multiple highly specific
blood biomarkers and test neurocognitive performance in less than 20 minutes. Combining
functional and biological evidence of injury, this multimodality test provides the necessary data
for an instant readout of brain health. We will train the algorithms that provide the test result to
recognize patterns in individual patients that are specific for TBI even in the presence of cognitive
decline or dementia. This distinction is critical to effective diagnosis in this patient age group,
where brain injuries due to falls or other causes are too often left undiagnosed. This work will
adapt a novel, effective testing system to the needs of our growing geriatric population, which will
enable rapid mTBI diagnosis and prognosis at the bedside with a single device. Development and
validation of this product to address the underdiagnosis of geriatric TBI and help prevent the
frequent debilitating outcomes that are clinically elusive due to neurocognitive decline and
dementia.

## Key facts

- **NIH application ID:** 10484862
- **Project number:** 1R44NS127732-01
- **Recipient organization:** BRAINBOX SOLUTIONS, INC.
- **Principal Investigator:** Timothy E Van Meter
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $471,835
- **Award type:** 1
- **Project period:** 2022-06-15 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10484862

## Citation

> US National Institutes of Health, RePORTER application 10484862, Multi-modality Test for improving precision of TBI diagnosis in the elderly. (1R44NS127732-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10484862. Licensed CC0.

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