# CARE4Kids: Data Coordinating Core

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2022 · $398,649

## Abstract

PROJECT SUMMARY ABSTRACT – Data Coordinating Core
Mild traumatic brain injury (mTBI) including concussion is a pressing public health issue for children in the United
States. In 2013, there were approximately 640,000 TBI-related emergency department visits among children
under 15 years alone. Concussions occurring in youth affect a greater number of individuals than concussions
in adults, and the distal impact of these concussions occurs over a greater number of years. Understanding
youth concussion in order to mitigate the impact of these injuries on the life span is a critical yet understudied
priority. Of particular importance are early and middle adolescents (EMA) who experience persistent post-
concussive symptoms (PPCS). PPCS as defined for this proposal refers to post-concussive symptoms (PCS)
lasting at least three months. While a minority of the mTBI population, these youth account for the majority of
morbidity, disability, and educational- and health-related costs. To better understand time to recovery, current
treatments, and the impact of PPCS, the Four Corners Youth Consortium (4CYC) has created a registry of
children and adolescents reporting to specialty clinics for concussion symptoms. Utilizing common data elements
(CDEs) from the National Institute of Neurological Disorders and Stroke (NINDS), the 4CYC Concussion Registry
captures participants' demographic and clinical data as well as functional assessments. The Data Coordinating
Core (DCC) at the University of Utah has served as the Data Coordinating Center for the 4CYC Concussion
Registry, making it uniquely suited to serve as the DCC in the current proposal. The median time between injury
and clinic visit is 16 days with an interquartile range of 8 to 28 days suggesting this is an effective method to use
for this proposal to study children suffering from PPCS. While clinical factors and assessments are useful for
identifying PPCS, a need exists to understand the biological mechanisms underlying this outcome. Biomarkers
such as blood protein levels, neuroimaging, and oculomotor function may help assess concussion symptoms
and degrees of recovery. To support these aims, the CARE4Kids DCC proposes the following 3 aims: Specific
Aim 1. To provide assistance in protocol design, study implementation and management, data collection and
management, efficient quality monitoring, study reporting and metrics to ensure uniform collection of blood
specimens, imaging, and clinical data across the CARE4Kids sites. Specific Aim 2. To provide logistical support
and technical expertise to coordinate the collection and storage of blood specimens at BioSEND and ensure the
adherence to the data quality and sharing requirements related to FITBIR submissions. Specific Aim 3. To
provide biostatistical leadership and expertise to support the analytical goals of the CARE4Kids Research Cores
and project. Successful implementation of these aims will result in a public resource connecting standardized
da...

## Key facts

- **NIH application ID:** 10485180
- **Project number:** 5U54NS121688-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** LAWRENCE Joseph COOK
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $398,649
- **Award type:** 5
- **Project period:** 2021-09-08 → 2027-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10485180

## Citation

> US National Institutes of Health, RePORTER application 10485180, CARE4Kids: Data Coordinating Core (5U54NS121688-02). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10485180. Licensed CC0.

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