# The International URBAN Alcohol Research Collaboration on HIV/AIDS (ARCH) Center

> **NIH NIH P01** · BOSTON MEDICAL CENTER · 2022 · $1,325,994

## Abstract

ABSTRACT
One quarter of the global population is infected with the bacillus Mycobacterium tuberculosis and is at risk of
developing active tuberculosis (TB) disease and death, especially persons living with HIV (PLWH). Alcohol use
is increasingly being recognized as a driver of the TB epidemic, and may be a vital means to mitigate HIV/TB
morbidity and mortality. TB preventive therapy (TPT) is an important approach in preventing the progression of
latent TB infection to active TB disease. However, TPT does not prevent new or repeat TB infection, thus
PLWH who drink alcohol may remain at increased risk for TB acquisition, even after receipt of TPT. Heavy
alcohol use is common among persons living with HIV (PLWH). While the increased risk for active TB is
attributed to alcohol-related immunosuppression leading to latent TB re-activation, the role of alcohol use in
acquiring new or repeat TB infection and progression to active TB disease after TPT has not been extensively
examined, including among PLWH. Those who complete TB treatment have extensive post-TB morbidity and
almost a 4-fold higher risk of mortality. The role of both heavy alcohol use and HIV in promoting lung disease
after TB treatment is not clear. The central goal of the International Uganda Russia Boston Alcohol Network
for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Center is to examine the role of alcohol use
on new TB acquisition, occurrence of active TB disease after TPT, and post-TB lung disease among PLWH.
This new knowledge will enable future development of interventions that can reduce alcohol’s impact on TB-
related morbidity and mortality among PLWH. The Center will be comprised of 4 components (Administrative
Core, Biostatistics and Data Management [BDM] Core, Uganda Project, Russia Project) that will work
synergistically to accomplish the following primary objectives: 1) Examine the role of alcohol use in driving
the acquisition of new TB infection and the occurrence of active TB disease after TPT in PLWH in Uganda
(Uganda Project). This new knowledge will inform potential new interventions to reduce risk of TB acquisition
and active disease; 2) Determine the relationship between alcohol use and lung disease after treatment for
active TB disease among PLWH and qualitatively evaluate factors to tailor alcohol and smoking interventions
in the setting of TB treatment in PLWH (Russia Project); 3) Conduct high quality data management and
statistical analyses for HIV/alcohol research (BDM Core); 4) Foster multidisciplinary international collaborations
to promote innovative and rigorous HIV/alcohol research (Administrative Core); and 5) Provide ongoing training
and mentoring to develop junior and mid-career investigators into future leaders in HIV/alcohol research
(Administrative Core). The structure of the International URBAN ARCH Center will ensure effective
administrative and scientific integration of a broad range of activities designed to synergistically grow the...

## Key facts

- **NIH application ID:** 10486108
- **Project number:** 5P01AA029541-02
- **Recipient organization:** BOSTON MEDICAL CENTER
- **Principal Investigator:** JEFFREY H. SAMET
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,325,994
- **Award type:** 5
- **Project period:** 2021-09-10 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10486108

## Citation

> US National Institutes of Health, RePORTER application 10486108, The International URBAN Alcohol Research Collaboration on HIV/AIDS (ARCH) Center (5P01AA029541-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10486108. Licensed CC0.

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