# Core - Biomarker Reference Laboratory (BRL)

> **NIH NIH U2C** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2022 · $210,741

## Abstract

The Biomarker Reference Laboratory (BRL) will be led by Dr. Sanford Stass and as a
component of the BCC will develop, refine, and standardize the biomarkers assays developed
by the Biomarker Development Laboratory. This BRL is a continuation of the University of
Maryland Baltimore Biomarker Reference Laboratory. UMB-BRL has for the past 15 years
provided active support of the EDRN, including testing of candidate biomarkers, development of
assays and technologies, and standardization of assay methods in collaboration with multiple
investigators in the EDRN. The proposed BRL includes a multi-disciplinary team of directors/co-
investigators and staff with broad knowledge, experience and expertise in application of
technology for biomarkers including reagent and assay development and implementation,
validation of laboratory methodology and assays, quality control for reagents and technologies,
evaluation of accuracy, precision, reproducibility and characteristics of performance including
sensitivity, specificity, and positive and negative predictive values. The BRL will bring DNA
methylation biomarkers from the BDL into a CLIA compliant laboratory using developed
standard operating procedures (SOPs), and extensive experience in collaborative studies in
biomarker validation.

## Key facts

- **NIH application ID:** 10486261
- **Project number:** 1U2CCA271885-01
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** JAMES G. HERMAN
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $210,741
- **Award type:** 1
- **Project period:** 2022-09-16 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10486261

## Citation

> US National Institutes of Health, RePORTER application 10486261, Core - Biomarker Reference Laboratory (BRL) (1U2CCA271885-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10486261. Licensed CC0.

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