# Enhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research Center

> **NIH NIH U2C** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2022 · $3,000,000

## Abstract

PLEDGE Abstract
The Precision Medicine Initiative’s (PMI’s) overarching goal is to transform our understanding of
the factors that contribute to health and disease, and ultimately, to leverage this understanding to
information how we prevent and treat disease. This bold objective will be operationalized in the
creation of a longitudinal cohort of 1 million individuals. The PMI’s coordinating center (CC) (called
Partnership in Learning around Engagement, Data, Genomics, and Environment, or “PLEDGE”)
operationalizes this vision, serving as a hub for the PMI Network leading the optimization of
participant engagement strategies, robust data infrastructure, facilitative support of researchers,
coordination and communication between the diverse stakeholders of the Network, and
responsibility for enrollment of the Cohort’s direct volunteers. PLEDGE’s goals are illustrated by
four proposed specific aims: 1) Support the network and its Steering Committee to establish,
implement, monitor and reach its programmatic goals. Serve as a visible national home for the
PMI, representing its mission and value to participants and to health; provide a ‘one stop shop’
storefront for all needs, inquiries, and provision of data access for high caliber research; 2) Enroll
a diverse group of highly engaged direct volunteers without sacrificing inclusiveness for quantity;
3) Harmonize technical practices among Healthcare Provider Organizations including data
standards, elements, and models, while nurturing innovation from network sites when conformity
is not beneficial. Apply stringent privacy and security safeguards; and finally, 4) Generate support
for PMI beyond the network’s personnel to continuously incorporate new knowledge and tools, by
deploying innovative contests, crowd sourcing, and matchmaking services.

## Key facts

- **NIH application ID:** 10486352
- **Project number:** 3U2COD023196-04S2
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** DAVID GLAZER
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $3,000,000
- **Award type:** 3
- **Project period:** 2016-07-06 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10486352

## Citation

> US National Institutes of Health, RePORTER application 10486352, Enhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research Center (3U2COD023196-04S2). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10486352. Licensed CC0.

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