# Pharmacometrics and Analytical Chemistry Core

> **NIH NIH P50** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2022 · $200,597

## Abstract

The Pharmacometrics and Analytical Chemistry Core (PACC) will further the goals of this multidisciplinary UC
San Diego MPRINT CET proposal by conducting highly coordinated research activities with the Clinical, Basic
Research and Data Science Projects and the Milk Analytics Core, with guidance from the Administrative Core.
Precise, high quality translation and clinical pharmacokinetic (PK) data will be generated to help address
hypotheses raised in each of the Projects. The infrastructure enabling the PACC lies in the established and
highly productive UC San Diego Pediatric Pharmacology Laboratory (PPL) within the Skaggs School of
Pharmacy and Pharmaceutical Sciences and Department of Pediatrics. Specific Aims of the Clinical, Basic
Science and Data Science Projects require quantification of antibiotics, their metabolites, and therapeutic
effects markers in a variety of clinical and animal model matrices. The PACC is well qualified to conduct these
quantitative assays and has experience with the small volumes and heterogeneous matrices associated with
PK samples that will be generated by the Projects, including breastmilk. The PACC possesses prior and
contemporary expertise in the processing of plasma, serum, whole blood, urine, cerebrospinal fluid, meconium,
hair shaft, as well as all mammalian tissue types. Additionally, the PACC will continue to expand upon its
capabilities to include quantification of drug metabolites in addition to their parent compounds. Quantification
of drugs and metabolites in breast milk, plasma, and other matrices will be accomplished by LC-MS/MS and/or
HPLC-UV. The PACC will also offer dedicated and specialized PK analysis to Project Leaders, including
innovative PK modeling and simulation and physiologically-based PK (PBPK) modeling. Finally, the PACC will
provide an optimal research and training environment in which to support the Clinical, Basic Science, and
Translational Science Projects.

## Key facts

- **NIH application ID:** 10487513
- **Project number:** 5P50HD106463-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Jeremiah D Momper
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $200,597
- **Award type:** 5
- **Project period:** 2021-09-10 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10487513

## Citation

> US National Institutes of Health, RePORTER application 10487513, Pharmacometrics and Analytical Chemistry Core (5P50HD106463-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10487513. Licensed CC0.

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