# The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC)

> **NIH NIH P30** · INDIANA UNIVERSITY INDIANAPOLIS · 2022 · $3,403,105

## Abstract

Summary (Overall)
The Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub will serve as a national resource for multi-
disciplinary expertise and knowledge in maternal and pediatric therapeutics. The MPRINT Data, Model,
Knowledge, and Research Coordination Center (DMKRCC) will support the MPRINT Centers of Excellence in
Therapeutics (CET) and Steering Committee to coordinate and expand research relating to maternal and
pediatric therapeutics. The DMKRCC will serve as the administrative component of the MPRINT Hub, coordinate
outreach and dissemination of MPRINT Hub activities, and will serve as a conduit between the MPRINT Hub
and the broader scientific community. Additionally, the MPRINT DMKRCC will organize annual MPRINT
meetings and educational activities, including webinars, to cultivate translational research in maternal and
pediatric therapeutics. The DMKRCC will identify, aggregate, and make available data, knowledge, and expertise
in maternal and pediatric therapeutics to the wider research, drug development, and regulatory communities.
Specifically, the DMKRCC will identify, evaluate, and collate pertinent data in a knowledgebase that will be made
available through a web portal; utilize and enhance pharmacometric modeling approaches such as
physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD); support clinical trial design; and
foster expertise in drug development and personalized therapy for maternal and pediatric populations. The
specific aims of this proposal will develop a cohesive organizational structure to support the research of the
MPRINT Hub as a whole as well as the individual cores within the DMKRCC. We will develop infrastructure to
facilitate data sharing and knowledge dissemination, and work with the CETs and Steering Committee to identify
and address changing needs of the maternal and pediatric communities.

## Key facts

- **NIH application ID:** 10487575
- **Project number:** 5P30HD106451-02
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Lang Li
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $3,403,105
- **Award type:** 5
- **Project period:** 2021-09-10 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10487575

## Citation

> US National Institutes of Health, RePORTER application 10487575, The Indiana University-Ohio State University Maternal and Pediatric Precision in Therapeutics Data, Model, Knowledge, and Research Coordination Center (IU-OSU MPRINT DMKRCC) (5P30HD106451-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10487575. Licensed CC0.

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