# Core B - Biospecimens

> **NIH NIH P50** · UNIVERSITY OF IOWA · 2021 · $49,568

## Abstract

The Iowa Neuroendocrine Tumor (NET) SPORE Biospecimens Core provides a coordinated, centralized, and 
dedicated core for the procurement, processing and annotation of biospecimens from patients in our Iowa 
Neuroendocrine Tumor Registry and also from SEER Residual Tissue Repositories. The primary goal of the 
Biospecimens Core is to procure a variety of biologic specimens on patients with neuroendocrine tumors. 
These specimens will include fresh or rapidly frozen specimens from patients who have signed the Iowa NET 
Registry consent as well as de-identified, formalin-fixed paraffin-embedded (FFPE) specimens obtained 
through the Surveillance Epidemiology and End Results (SEER) residual tissue repository (RTR). All 
specimens will be tracked and stored under conditions that optimize their utility for molecular studies, assuring 
the Iowa NET SPORE investigators have access to a large number of a wide variety of NET tumor, normal, 
and germline specimens. 
All biospecimens will be collected, tracked and distributed to SPORE researchers following the established 
protocols of the Iowa Tumor Procurement Core (TPC) in the Holden Comprehensive Cancer Center (HCCC) 
and the Iowa SEER. All specimens are collected and processed under tight quality control, tracked and 
distributed to SPORE researchers or banked for future SPORE research projects. The Core tracks the 
acquisition, distribution, and results obtained on these specimens, allowing integration with clinical and other 
data collected in research projects. The Core benefits from the expertise in the HCCC, but does not duplicate 
its services. The Core supports each of the full and developmental projects. There has been extensive 
utilization of these biospecimens with resulting clinical and phenotypic data already in our Iowa NET Database. 
We will continue to accrue new patient samples as well as repository FFPE specimens and will continually 
work with investigators to utilize this increasingly valuable resource for these orphan tumors. 
Specific Aims of the Biospecimens Core are: 1) Collect, process, bank and distribute excess surgical 
specimens and/or blood/buccal swabs from patients and family members who have signed consent to 
participate in the Iowa NET Registry; 2) Acquire, process, and distribute de-identified neuroendocrine tumor 
FFPE specimens obtained through the Iowa Virtual Tumor Repository and SEER Residual Tissue Repository; 
3) Provide accurate diagnosis and grade on all tumor specimens according to North American Neuroendocrine 
Tumor Society (NANETS) guidelines; 4) Work with the Biostatistics and Bioinformatics Core to maintain data 
obtained from Iowa NET Registry biospecimens and SEER Repository biospecimens to further collaborative 
research leading to improved long term outcomes for patients with NETs.

## Key facts

- **NIH application ID:** 10487598
- **Project number:** 3P50CA174521-05S3
- **Recipient organization:** UNIVERSITY OF IOWA
- **Principal Investigator:** Charles Michael Knudson
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $49,568
- **Award type:** 3
- **Project period:** 2015-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10487598

## Citation

> US National Institutes of Health, RePORTER application 10487598, Core B - Biospecimens (3P50CA174521-05S3). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10487598. Licensed CC0.

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