# Evaluation of HepaRG cells as a screen for chemical toxicity and assay optimization

> **NIH NIH N01** · BATTELLE MEMORIAL INSTITU · 2021 · $682,169

## Abstract

The overall goal of this project is to further validate and refine study design for the selection of 3D HepaRG cells, or spheroids, as a model system in the screening and prioritization of chemicals for test at DNTP. This project also includes an in vitro assessment of aqueus film forming foams (AFFFs) in 2D HepaRG cells.
Keywords: aqueous film forming foam, aqueous fire fighting foam, AFFF, HepaRG, primary human hepatocytes, PHH

## Key facts

- **NIH application ID:** 10487856
- **Project number:** 273201700005C-P00010-9999-19
- **Recipient organization:** BATTELLE MEMORIAL INSTITU
- **Principal Investigator:** BARNEY SPARROW
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $682,169
- **Award type:** —
- **Project period:** 2017-09-26 → 2022-09-25

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10487856

## Citation

> US National Institutes of Health, RePORTER application 10487856, Evaluation of HepaRG cells as a screen for chemical toxicity and assay optimization (273201700005C-P00010-9999-19). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10487856. Licensed CC0.

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