# Targeted Healthcare Engineering for Systems Interventions in Stroke (THESIS)

> **NIH AHRQ R18** · UNIVERSITY OF CHICAGO · 2022 · $619,204

## Abstract

Project Summary/Abstract
Nearly 800,000 people in the United States each year are affected by stroke, which remains the leading cause
of adult disability and 5th leading cause of death. Several proven medical and surgical treatments exist for
acute stroke. However, diagnostic error and resultant treatment delays contribute to missed opportunities to
reduce death and disability in acute stroke patients. Indiscriminate neurologic consultation and over-testing in
the emergency department (ED) will stress and deplete currently available staff and resources and are not
practical solutions. Furthermore, incomplete problem analysis and risk assessments can lead to unintended
consequences of an intervention. Although recommendations and pathways exist for stroke evaluation and
management, none has been systematically engineered, designed, or tested to identify and effectively address
system failures especially in diagnostic error. The Targeted Healthcare Engineering for Systems Interventions
in Stroke (THESIS) study will bring together dynamic learning laboratories consisting of stroke neurology,
emergency medicine, informatics, engineering, and health services experts at 3 large, diverse healthcare
systems in Chicago with experience in the application of systems engineering, problem analysis, design and
development, implementation, and evaluation methods to identify and test solutions to reduce diagnostic error
and resultant delays to evidence-based treatments for acute stroke patients in the ED.

## Key facts

- **NIH application ID:** 10488191
- **Project number:** 5R18HS027264-04
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** JANE Louise HOLL
- **Activity code:** R18 (R01, R21, SBIR, etc.)
- **Funding institute:** AHRQ
- **Fiscal year:** 2022
- **Award amount:** $619,204
- **Award type:** 5
- **Project period:** 2019-09-30 → 2025-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10488191

## Citation

> US National Institutes of Health, RePORTER application 10488191, Targeted Healthcare Engineering for Systems Interventions in Stroke (THESIS) (5R18HS027264-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10488191. Licensed CC0.

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