# Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress

> **NIH NIH R01** · ILLINOIS INSTITUTE OF TECHNOLOGY · 2022 · $502,959

## Abstract

IIT Project Summary/Abstract
The objective of this proposal is to demonstrate a viable, functionally integrated multivariable
artificial pancreas that will mitigate meal, physical activity and acute psychological stress
challenges without any manual inputs to better regulate glucose levels of people with diabetes.
The first generation of artificial pancreas (AP) systems, the hybrid closed-loop AP, collects data
from continuous glucose monitoring devices and relies on manual user inputs for mitigating the
effects of meals and physical activities. Acute psychological stress and many other physical
activities besides planned exercise can affect blood glucose levels and cause challenges to
maintaining euglycemia for people with type 1 diabetes. Various physical activities and acute
psychological stress events affect the metabolism and sensitivity to insulin in different ways.
Hence, their types, intensities and durations, and their individual and concurrent presence must
be detected in order to determine the optimal insulin administration. The multivariable artificial
pancreas approach provides a well-integrated and user-friendly technology with minimal burden
on the user and mitigates the effects of unexpected physical activities and acute psychological
stress inducements. Additionally, this technology would be safer by reducing the number and
duration of hypoglycemic and hyperglycemic events, compared to APs based exclusively on
continuous glucose monitoring device data. Such multivariable AP systems can only be
developed by using a sophisticated multivariable approach that uses real-time information from
continuous glucose monitoring devices and physiological variables obtained from wearable
devices worn in free-living daily life.

## Key facts

- **NIH application ID:** 10488195
- **Project number:** 5R01DK130049-02
- **Recipient organization:** ILLINOIS INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** Ali Cinar
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $502,959
- **Award type:** 5
- **Project period:** 2021-09-12 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10488195

## Citation

> US National Institutes of Health, RePORTER application 10488195, Multivariable Artificial Pancreas System to Detect and Mitigate the Effects of Unannounced Physical Activities and Acute Psychological Stress (5R01DK130049-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10488195. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*