# Nutrition, Genetics, and Evolution in the Cavefish Model of Autism-like Disorders

> **NIH NIH P20** · UNIVERSITY OF HAWAII AT MANOA · 2022 · $214,413

## Abstract

The overarching goal of this research proposal is to identify new therapies by systemically investigating how the gut microbiota through nutrition alters brain functions, particularly by modifying activities within and between brain regions. The short-term goals of this research program are to develop tools to dissect the mechanisms that drive autism spectrum disorder (ASD)-like symptoms in a teleost model, which exhibits a similar composition of the gut microorganism to the ones of autism patients and core ASD-like behaviors.

## Key facts

- **NIH application ID:** 10488620
- **Project number:** 5P20GM125508-05
- **Recipient organization:** UNIVERSITY OF HAWAII AT MANOA
- **Principal Investigator:** Edward G Ruby
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $214,413
- **Award type:** 5
- **Project period:** 2018-08-15 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10488620

## Citation

> US National Institutes of Health, RePORTER application 10488620, Nutrition, Genetics, and Evolution in the Cavefish Model of Autism-like Disorders (5P20GM125508-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10488620. Licensed CC0.

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