# Systems Biology Core

> **NIH NIH P20** · UNIVERSITY OF NEBRASKA LINCOLN · 2022 · $464,466

## Abstract

PROJECT SUMMARY/ABSTRACT
The broad, long-term goal of the Systems Biology Core (SBC) within the Nebraska Center for Integrated
Biomolecular Communication (CIBC) is to serve as a sustainable resource that enables CIBC, the University of
Nebraska-Lincoln (UNL), and other academic and industrial researchers to investigate complex biological
systems. SBC provides a diverse set of OMICS (i.e., lipidomics, metabolomics, and proteomics), microscopy,
and structural biology services, which afford distinct and invaluable views of an entire system and, accordingly,
are critical to the needs of CIBC Project Leaders and other Center members. The successful application of
microscopy, OMICs, and structural biology techniques are highly dependent on the expertise and experience of
the investigator. Understanding the challenges these methods present to novice and new investigators has
informed the overarching vision of SBC. SBC eschews the typical sample-based service model of a common
facility and instead has adopted a personalized collaborative approach to enable the correct utilization of
microscopy, OMICs, and structural biology methods by new investigators. In this regard, SBC provides
assistance and training from project conception, experimental design, and sample preparation through
implementation and dissemination. An important goal of SBC is enabling the long-term adoption of SBC
technologies through personalized hands-on training and workshops—in other words, SBC personnel are
collaborators and instructors. During Phase 1, SBC established its service pipeline and is providing efficient and
high-quality data to CIBC personnel. SBC created the critical infrastructure for managing projects, samples, and
data and the rapid dissemination of information to investigators. Building on the momentum and successes from
Phase 1, the goal of SBC for Phase 2 is to grow and improve SBC service in response to the needs of CIBC
Project Leaders and other Center members and to support CIBC in achieving its overall goals and long-term
Center sustainability. This will be achieved by pursuing the following specific aims: 1) provide high-quality
OMICs, microscopy, and structural biology assistance to CIBC projects to ensure investigators have adequate
and timely access to core services, 2) enhance existing SBC OMICs techniques by expanding MS imaging,
lipidomics, proteomics, and targeted metabolomics capabilities and improving the efficiency and throughput of
the OMICS technology through automation, and 3) expand and enhance SBC scientific outreach services. The
anticipated outcomes of SBC in Phase 2 are improved and expanded services that addresses the evolving needs
of SBC clients while continuing to provide high quality and timely results. SBC will also strive to increase the
throughput and efficiency of the service pipeline, expand the SBC user-base, and provide additional training
opportunities that enables the adaption of OMICS, microscopy, and structural biology by non...

## Key facts

- **NIH application ID:** 10488658
- **Project number:** 5P20GM113126-07
- **Recipient organization:** UNIVERSITY OF NEBRASKA LINCOLN
- **Principal Investigator:** ROBERT POWERS
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $464,466
- **Award type:** 5
- **Project period:** 2016-08-15 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10488658

## Citation

> US National Institutes of Health, RePORTER application 10488658, Systems Biology Core (5P20GM113126-07). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10488658. Licensed CC0.

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