# Chromatin remodeling at cell cycle exit

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $314,526

## Abstract

Project Summary/Abstract
Cell proliferation must be precisely controlled during development to produce tissues of the correct shape,
composition and size. Terminal differentiation is often associated with exit from the cell cycle and coupled with
a switch to a permanently postmitotic state. This is an important developmental process, as permanent exit
from the cell cycle is likely to represent the most common cellular state in adult animals. Our data indicates a
critical role for specific nucleosome remodelers in proper initiation and maintenance of cell cycle exit. This is
consistent with our finding that accessibility at many gene regulatory elements also changes during cell cycle
exit. The goal of our proposed research is to understand how cell cycle gene expression is shut down
at the right places and times during development to establish and maintain a stable postmitotic state in
differentiating tissues. To accomplish this, we propose three aims: 1. To define the specific gene expression
and regulatory element accessibility changes that are due to cell cycle exit and how they are altered upon
forced cell cycle re-entry 2. To determine how developmental signals coordinate cell cycle exit with
differentiation events and 3. To understand the role of specific nucleosome remodelers in promoting cell cycle
exit.

## Key facts

- **NIH application ID:** 10488672
- **Project number:** 5R01GM127367-05
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Laura A Buttitta
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $314,526
- **Award type:** 5
- **Project period:** 2018-08-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10488672

## Citation

> US National Institutes of Health, RePORTER application 10488672, Chromatin remodeling at cell cycle exit (5R01GM127367-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10488672. Licensed CC0.

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