# Duke Cancer Health Disparities P20 SPORE

> **NIH NIH P20** · DUKE UNIVERSITY · 2022 · $1,050,058

## Abstract

ABSTRACT – Overall
Cancer health disparities span the continuum of cancer care, including prevention, screening, early detection,
diagnosis, interception, treatment and survivorship, and are driven by a complex interplay between social,
psycho-social, lifestyle, environmental, structural, and biological determinants of health. This Duke Cancer
Health Disparities (DCHD) P20 SPORE application evolved from institutional efforts to address this complex,
multi-level problem, and represents the work of a group of basic, translational, clinical and population scientists
working collaboratively and synergistically to address disparities at particular points in the cancer disparity
continuum, while recognizing the complexities of the larger problem of achieving cancer health equity. Our
OVERALL GOAL is to develop or improve new or existing interventions and therapies through a better
understanding of cancer disparities prevalent in the Duke Cancer Institute’s catchment area. We propose the
following Aims: provide the infrastructure, oversight, and resources to conduct innovative translational research
to reduce cancer disparities through two projects focused on under-studied disparities (Aim 1); ensure availability
of expert support through Administrative and Shared Resource Cores (Aim 2); seed Developmental Research
Program (DRP) projects and grow the cancer disparities research community (Aim 3); and complete planning
and transition activities in preparation of a P50 SPORE application, including participating in and leading inter-
SPORE activities (with other P20s and with P50 SPOREs) that enhance our collective impact (Aim 4). We
propose two Projects. Project 1 is entitled “Race-related RNA splicing in non-small cell lung cancer: functional
interrogation and therapeutic targeting”. Project 2 is entitled “Racial differences in host immune response and
gastric carcinogenesis: translating underlying biology to promote gastric cancer interception”. Our two P20
Projects will be supported by an Administrative Core, a Biospecimen/Pathology Core (Core 1), and a
Biostatistics and Bioinformatics Core (Core 2). DRP projects funded by the P20 may graduate into full
projects for the future P50 SPORE. The expected outcomes of these aims are to conduct groundbreaking
research in cancer health disparities, to develop novel approaches to mitigate these disparities, and to prepare
and submit a full DCHD P50 SPORE application for the continuation and expansion of these efforts.

## Key facts

- **NIH application ID:** 10488710
- **Project number:** 5P20CA251657-03
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** STEVEN R PATIERNO
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,050,058
- **Award type:** 5
- **Project period:** 2020-09-14 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10488710

## Citation

> US National Institutes of Health, RePORTER application 10488710, Duke Cancer Health Disparities P20 SPORE (5P20CA251657-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10488710. Licensed CC0.

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