ABSTRACT – Administrative Core The Administrative Core of the Duke Cancer Health Disparities (DCHD) P20 SPORE is responsible for organizing and supporting two full translational research Projects; two Shared Resource Cores; a Developmental Research Program (DRP); and a Pre-CEP (Career Enhancement Program, supported by institutional resources), as the forerunner of our future P50 CEP. The Core is responsible for transition planning for this DCHD P20 to compete for a full P50 SPORE grant. The Core will provide leadership, coordination, oversight, infrastructure, and support personnel to facilitate administrative management; promote integration, communication, and collaboration; ensure fiscal and regulatory compliance; and oversee data operations, scientific rigor, and research progress. By serving these functions, the Core will allow investigators to focus on conducting and disseminating translational science supported by this Program. Steven Patierno, PhD, contact PI of this P20 SPORE, will lead this Core. Dr. Patierno will receive expert advice, assistance, and guidance from three oversight bodies: an Executive Committee (EC) of all Project Leaders, and Core and Program Directors, as well as Internal (IAB) and External Advisory Boards (EAB), both of which include patient advocates. The team also benefits from an experienced Administrator, and professionals with extensive fiscal and regulatory compliance experience. The P20 SPORE’s strong leadership and infrastructure, bolstered by Duke’s commitment to and investment in cancer disparities research, will accelerate advancement toward our goal of developing precision medicine interventions to mitigate cancer health disparities. The Specific Aims of the Administrative Core are to provide administrative management and oversight (Aim 1); provide financial management and ensure compliance with fiscal and research policies (Aim 2); provide oversight of all data operations (Aim 3); promote integration within the P20 SPORE and the Institution (Aim 4); provide scientific management to evaluate Program and research progress (Aim 5); and plan transition of the DCHD P20 to a full P50 Cancer Disparities SPORE (Aim 6). The Core will monitor research progress and productivity, scientific rigor and transparency, and effective use of Shared Resource Cores. With the EC, the Core will lead strategic planning and implementation of activities to prepare this Program’s competitive P50 application; develop and implement strategies to address progress, plans, challenges, and solutions, including initiation of formal processes to replace Projects when needed; and evaluate DRP Project proposals. This Core also will connect with quality assurance oversight provided by Duke Office of Regulatory Affairs and Quality. Finally, through formal evaluation processes involving an external evaluation contractor, the IAB and EAB, the Core will facilitate assessment of all activities and implement recommendations, guidance, and directio...