# CWRU Center for Excellence on the Impact of Substance Use on HIV

> **NIH NIH P30** · CASE WESTERN RESERVE UNIVERSITY · 2022 · $3,213,141

## Abstract

Project Summary - Overview
 The newly developed CWRU (Case Western Reserve University) Center for Excellence on the
Impact of Substance Use on HIV was conceived in August 2017 and was initiated to effectively
promote excellence in basic, translational, and clinical research concerning the intersection between
substance use and HIV. The Center for Excellence includes 12 NIDA-funded Investigators who
collectively hold 9 R01, 2 DP1, 3 R34, 2 R44, 1 U01, and 2 K01 drawn from the CWRU School of
Medicine, University Hospitals Cleveland Medical Center, MetroHealth Medical Center, the Cleveland
Clinic Foundation, the Louis Stokes Cleveland Veterans Administration Medical Center, the CWRU
Mandel School of Applied Social Sciences, the Begun Center for Violence Prevention Research and
Education, and the Cuyahoga County, Lorain County, and City of Cleveland Departments of Health.
Major research strengths in the Center for Excellence include impact of drug use on HIV
immunopathogenesis, HIV latency and Cure, NeuroAIDS, gastrointestinal dysfunction, sexual risk
behavior, and HIV and HCV co-infections. Our studies are anchored by advanced computational,
systems biology, biomimetic models, and induced pluripotent stem cell (iPSC) technologies that
provide the opportunity to perform meta-omics analyses of the impact of opioid, methamphetamine,
cannabis, and cocaine misuse on several clinical, virological, immunological, behavioral, and
neurological outcomes of HIV disease. The Center for Excellence has the following Specific Aims:
• Provide scientific leadership to position the Center at the forefront of substance use
 disorder research and function as a national research resource for the study of drug use
 in persons with HIV.
• Establish an administrative infrastructure that maintains fiscal and management oversight
 of the Cores.
• Apply advanced Computational Biology, Primary Cells, Biomimetic models, and iPSC-
 derived Cells to study of the impact of substance use on HIV disease.
• Support translational, clinical, and behavioral research through access to unique clinical
 cohorts of persons with substance use disorder with HIV and at risk for HIV.
• Accelerate junior faculty development and encourage experienced faculty to enter the
 substance use research arena to support the next generation of investigators.
• Participate in community outreach.

## Key facts

- **NIH application ID:** 10489341
- **Project number:** 5P30DA054557-02
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Alan David Levine
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $3,213,141
- **Award type:** 5
- **Project period:** 2021-09-15 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10489341

## Citation

> US National Institutes of Health, RePORTER application 10489341, CWRU Center for Excellence on the Impact of Substance Use on HIV (5P30DA054557-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10489341. Licensed CC0.

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