# Mosaic loss of Y chromosome in blood and heart failure

> **NIH NIH R01** · UNIVERSITY OF VIRGINIA · 2022 · $448,852

## Abstract

SUMMARY
Recent technological advances indicate that somatic DNA mutations accumulate with age and are remarkably
prevalent. The accumulation of mutations in blood cells has been associated with increases in all-cause
mortality and cardiometabolic diseases. Studies have focused on the precancerous clonal hematopoiesis state
that results from mutations in “driver” genes that recurrently mutate in blood cancers. However, this class of
mutations represent a small fraction of the total somatic mosaicism that occurs in blood. Mosaic loss of the Y
chromosome (mLoY) in blood is the most common post-zygotic mutation in humans. Epidemiological studies
have associated mLoY with all-cause mortality and a number of age-associated diseases. However, it is
unknown whether there is a causal connection between mLoY and cardiovascular disease. Here, we will
employ multiple murine models to assess the impact of mLoY in heart failure, and investigate this relationship
at a mechanistic level.

## Key facts

- **NIH application ID:** 10489372
- **Project number:** 5R01AG073249-02
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** KENNETH WALSH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $448,852
- **Award type:** 5
- **Project period:** 2021-09-15 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10489372

## Citation

> US National Institutes of Health, RePORTER application 10489372, Mosaic loss of Y chromosome in blood and heart failure (5R01AG073249-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10489372. Licensed CC0.

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