# Shared Resources Core 1:  Genomics/Epigenomics Core

> **NIH NIH P01** · ROCKEFELLER UNIVERSITY · 2022 · $189,245

## Abstract

PROJECT SUMMARY (MAJEWSKI)
Mutations in histone and modifier genes in cancers have dramatic downstream effects on the landscape of the
epigenome – chromatin state and DNA methylation – with eventual secondary outcomes manifested in gene
expression and cellular phenotypes. Modern functional genomics approaches provide invaluable tools to study
the effects of this epigenome-mediated cascade. In this Core activity, we will establish and provide a set of
genomics tools and computation methods to elucidate the mechanisms through which histone variants impact
the epigenome, transcriptome, and the cell identity during neoplastic transformation.

## Key facts

- **NIH application ID:** 10489404
- **Project number:** 5P01CA196539-08
- **Recipient organization:** ROCKEFELLER UNIVERSITY
- **Principal Investigator:** Jacek Majewski
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $189,245
- **Award type:** 5
- **Project period:** 2015-09-09 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10489404

## Citation

> US National Institutes of Health, RePORTER application 10489404, Shared Resources Core 1:  Genomics/Epigenomics Core (5P01CA196539-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10489404. Licensed CC0.

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