Abstract: GLNARCH OVERALL This Great Lakes Native American Research Centers for Health (GLNARCH) application aligns established partnerships to generate a network of resources for AI/AN programs as well as support ongoing successful initiatives. We have identified opportunities to establish synergistic education, training, and research within the Indian Health Service Bemidji Region with increased focus on including Tribal Colleges and Universities (TCU). This application proposes an unprecedented endeavor to engage AI/AN populations in cultivating an indigenized (culturally responsive) research and training agenda. This agenda will follow the common AI/AN cultural theme of holistic health and wellness connected to the land and the unique natural resources of the Great Lakes region. The Student Career Enhancement Project (SCEP) proposes exciting opportunities to expose AI/AN students to remote learning, thereby connecting them in an indigenous styled network whilst also preparing them for 21st century education. The Capacity Building Project is responsive to recent experiences and evaluation reports to seek even better research networks and resource sharing within the GLNARCH service area, which is geographically broad and underfunded. The Capacity Building Project proposes unique initiatives to better engage TCUs via the established and successful Native American Environmental Health Research (NEHR) network. Leveraging modern technology will increase both research and training capacity in the tribal community and academic spheres. The proposed team has successfully implemented over 16 years of successful and impactful GLNARCH programming. They possess the necessary skills, institutional environment, and connections to execute these aims.