# Detecting the disruption and recovery of synaptic connectivity after TBI

> **NIH NIH UH3** · GEORGETOWN UNIVERSITY · 2022 · $406,067

## Abstract

PROJECT SUMMARY
 The rationale for this proposal is that synaptic integrity is essential for neuronal function. Disruptions to
synaptic integrity are downstream of common TBI pathophysiological events including neuronal cell death,
axonal injury, p-tau aggregation, and neuroinflammation. The ability to detect discrete changes in synaptic
integrity – regardless of the upstream mechanism of synapse loss – will allow clinicians to track the ability of
clinical interventions to improve chronic outcome in patients. The objective of this proposal is to use measures
of synaptic integrity to predict chronic behavioral outcomes, and to validate Hcorr as a non-invasive marker of
synaptic integrity for use in TBI.

## Key facts

- **NIH application ID:** 10489713
- **Project number:** 5UH3NS106941-05
- **Recipient organization:** GEORGETOWN UNIVERSITY
- **Principal Investigator:** MARK P BURNS
- **Activity code:** UH3 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $406,067
- **Award type:** 5
- **Project period:** 2018-04-15 → 2025-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10489713

## Citation

> US National Institutes of Health, RePORTER application 10489713, Detecting the disruption and recovery of synaptic connectivity after TBI (5UH3NS106941-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10489713. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*