# HTORR High Priority Alzheimer's Disease and Related Dementias Human Biospecimen Resource

> **NIH NIH U42** · NATIONAL DISEASE RESEARCH INTERCHANGE · 2022 · $321,405

## Abstract

Program Director/Principal Investigator (Last, First, Middle): Bell, Thomas, J.
Project Summary:
The development of effective treatments or cures for a wide range of diseases requires translational studies that
are directly relevant to human pathophysiology. The use of human biospecimens plays a key role in accelerating
scientific discoveries in neurological research by providing scientists with a direct experimental model system to
advance understanding of pathogenesis and treatment of neurological disease, including Alzheimer’s disease
and related dementias (AD/ADRD). To address several complex issues facing AD/ADRD research, including
disease etiology as well as the development of improved diagnostics and treatment strategies, investigators
require access to a unique human tissue resource that could provide rigorous and uniform collection of human
biospecimens from defined cohorts of post mortem AD/ADRD and normal control donors to yield consistent and
reproducible experimental results for inventive and groundbreaking studies. As a leading human tissue provider
for the biomedical research community, the National Disease Research Interchange (NDRI) is a 501(c)(3), not-
for-profit organization that remains at the forefront of coordinating biospecimen procurement to match the needs
of advancing scientific experimental methodologies, enabling cutting-edge research. For over 30 years, NDRI
has received NIH funding for the parent award to this administrative supplement, the Human Tissue and Organs
for Research Resource (HTORR) Grant Number: U420DO11158. To address the high priority areas of research
for AD/ADRD that require both post mortem biospecimen collection that are beyond the scope of HTORR, NDRI
is expanding their capabilities to create a new resource, the AD/ADRD Human Biospecimen Resource (ADBR),
funded by the active award 3U42OD011158-30S1. In Program Year 3 of the ADBR, NDRI continued to follow
the recommendations from ADBR Advisory Council regarding biospecimen collection and distribution for the
ADBR that align with an unmet or under represented need in the field. For the current proposal to continue the
progression of the ADBR, NDRI proposes to enhance the success of ADBR’s service to investigators in PY4 by
1) providing a nationwide network of TSS to provide access to diverse post mortem diseased and non-diseased
donor cohorts, 2) recovering and distributing CNS tissues in addition to other tissues and fluids of interest, and
3) enhancing communication to the biomedical research community to recruit new ADBR investigators and
assess unmet needs of the AD/ADRD field. In contrast to similar resources, the ADBR’s extensive outreach
efforts and customized approach to investigator needs are key differentiators for the resource.
Collectively, the ADBR’s goals and efforts provides a dynamic and synergistic NIH-funded resource to
support the advancement of critical unmet research needs for the AD/ADRD research community.
Relevance: As the mo...

## Key facts

- **NIH application ID:** 10489968
- **Project number:** 3U42OD011158-31S3
- **Recipient organization:** NATIONAL DISEASE RESEARCH INTERCHANGE
- **Principal Investigator:** Thomas J Bell
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $321,405
- **Award type:** 3
- **Project period:** 2021-09-17 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10489968

## Citation

> US National Institutes of Health, RePORTER application 10489968, HTORR High Priority Alzheimer's Disease and Related Dementias Human Biospecimen Resource (3U42OD011158-31S3). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10489968. Licensed CC0.

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