PCEC Project Summary Immunotherapy with immune checkpoint inhibitors represents an important domain of precision oncology as a biomarker-driven approach to cancer treatment. However, the benefits of precision oncology among African Americans as a disparity population may be limited by their lack of representation in genomic research that informs immunotherapy discoveries. There is longstanding concern about the representation of African Americans in genomic research with acknowledgement that genomic literacy and medical mistrust are barriers to genomic research participation. The proposed Patient and Community Education Core (PCEC) will offer services to support high levels of engagement among African American study participants as well as the broader African American community in metropolitan Detroit. The PCEC will the use the HealthLink model, a participatory research approach, to convene a P20 program-specific Cancer Action Council. This council will be comprised of cancer survivors, caregivers, and advocates who will collaborate with the PCEC team and study investigators to increase genomic literacy by building awareness of precision oncology, genomic research, and immunotherapy; directly address medical mistrust and suspicion of medical trials among African American patients and community members through culturally appropriate educational approaches; and help to plan and conduct community dialogues that will build strong relationships between study investigators and community members. PCEC aims are to: Aim 1: Coordinate a council of local community stakeholders – the P20 Cancer Action Council (CAC) - that will collaborate with the Patient and Community Engagement Core (PCEC) team on the development and execution of PCEC services. Aim 2: Implement strategies to increase genomic literacy and awareness of immunotherapy among African American patients and community members. Aim 3: Provide ongoing feedback to all projects on strategies to optimize recruitment and retention of African American participants. Aim 4: Support dissemination of research project progress and findings to study participants and community members. The PCEC is distinct from the other proposed cores in its focus on the ways in which community stakeholder involvement can improve patient/participant experience, and this core will ensure that community members are well-informed regarding the scientific and equity-based rationale for the proposed studies as well as developmental projects.