# Human Immune Monitoring Core

> **NIH NIH P01** · STANFORD UNIVERSITY · 2022 · $1,107,746

## Abstract

Summary
The Immune Monitoring and Data Management Core (IMDMC) will be responsible for sample processing and
banking, comprehensive and standardized immune monitoring of those samples, and archiving and organization
of data generated. Sample processing and banking will be performed through the Stanford Biobank, using well-
developed systems and standard operating procedures (SOPs). The Stanford Human Immune Monitoring Center
(HIMC) will perform highly comprehensive assays of immune phenotype and function on both pre-existing and
newly collected samples. These will include standardized O-Link cytokine arrays, CyTOF immunophenotyping,
phosphosignaling flow cytometry, HLA typing, whole blood gene expression, and hemagglutinin inhibition (HAI)
assays; as well as new data types including microbiome, metabolomics, methylation, TCR sequencing, ATACseq
on sorted cells, single cell gene expression via BD Rhapsody, flu antigen arrays, and antibody glycosylation
analysis. Quality control measures will be performed on all assays, and data uploaded and organized via an
existing online database, Stanford Data Miner (SDM). SDM will allow integration with existing data, across
assays, and with clinical and demographic data. It will facilitate access by all associated investigators, as well
as extraction for upload to the public ImmPort database.
Relevance: The IMDMC will provide access to a suite of comprehensive, state-of-the-art immune assays, which
have already been applied to many existing samples. This unmatched set of samples, technologies, and
aggregated data will facilitate the discovery of new metrics and mechanisms of immune aging, vaccine
responsiveness, and many other avenues of research.

## Key facts

- **NIH application ID:** 10491677
- **Project number:** 5P01AI153559-02
- **Recipient organization:** STANFORD UNIVERSITY
- **Principal Investigator:** Holden T. Maecker
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $1,107,746
- **Award type:** 5
- **Project period:** 2021-09-21 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10491677

## Citation

> US National Institutes of Health, RePORTER application 10491677, Human Immune Monitoring Core (5P01AI153559-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10491677. Licensed CC0.

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