# Brief Transdiagnostic Treatment for Anxiety Disorders and PTSD in South Africa: A Hybrid-Effectiveness Trial

> **NIH NIH K01** · MASSACHUSETTS GENERAL HOSPITAL · 2022 · $184,005

## Abstract

Background: Posttraumatic stress disorder (PTSD) and anxiety disorders are highly prevalent and a leading
cause of disability in low and middle-income countries (LMICs). My long-term career goal is to address the
burden posed by these disorders by becoming a leading expert in the implementation and dissemination of
evidence-based treatments (EBTs) for these disorders for use in LMICs. This goal is motivated by observations
from the literature and my own work. Despite the development of EBTs, an overwhelming majority of those in
need (i.e., 85%) in LMICs do not receive treatment and, when they do, it is not empirically based. Despite the
clear need for EBTs in LMICs, there are three primary barriers associated with the implementation of EBTs in
these areas. These barriers include: (1) EBTs tend to be single disorder focused only treating one disorder at a
time, (2) they are long in duration (e.g., 12-16 treatment sessions to treat one disorder), and (3) they tend to be
complex and require a high level of skill to administer. Given the low availability of highly trained providers in
LMICs, using an approach that is brief, culturally congruent, and less complex than typical EBTs is ideal for
reducing these barriers. Proposed Study. The current study aims to evaluate a brief transdiagnostic treatment
for anxiety disorders and PTSD (False Safety Behavior Elimination Treatment; F-SET; Schmidt et al., 2012) for
use in South African primary care clinics. The aims follow a well-established implementation and dissemination
model (PRISM; Feldstein & Glasgow, 2008) for all study aims. First, we will conduct in-depth qualitative
interviews with patients (n=24) and providers and staff (n=10) to assess key barriers and facilitators to the
implementation and sustainability of the F-SET intervention in South African primary care clinics (Specific Aim
1). Second, the F-SET intervention and implementation strategy will be adapted based on the findings from the
qualitative study (Specific Aim 2). Third, we will conduct a randomized hybrid effectiveness-implementation trial
to assess the effectiveness of the adapted F-SET and explore facilitators and barriers to implementation
(Specific Aim 3). We will use a mixed methods approach (qualitative and quantitative) to evaluate the F-SET
intervention administered by primary care nurses compared to an enhanced standard care control group in a
sample of individuals with anxiety disorders and PTSD (N=60). We will evaluate the feasibility and acceptability
of implementation as measured by: (1) patient participation and retention and (2) provider’s perceptions of
barriers and facilitators of F-SET. Provider fidelity and quality of treatment delivery will be used as moderators.
These data will be used to submit an R01 for a fully powered trial with clinic randomization in Year 4. Training
Aims: This K01 proposal is will provide me with training needed to achieve my long-term career goal through
training in: (1) the conducting c...

## Key facts

- **NIH application ID:** 10491868
- **Project number:** 5K01TW012180-02
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Kristina Jo Korte
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $184,005
- **Award type:** 5
- **Project period:** 2021-09-23 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10491868

## Citation

> US National Institutes of Health, RePORTER application 10491868, Brief Transdiagnostic Treatment for Anxiety Disorders and PTSD in South Africa: A Hybrid-Effectiveness Trial (5K01TW012180-02). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10491868. Licensed CC0.

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