# Molecular Oncology Program

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2022 · $107,810

## Abstract

MOLECULAR ONCOLOGY PROGRAM (MOP)
PROJECT SUMMARY/ABSTRACT
The central theme of the Molecular Oncology Program (MOP) is to identify fundamental cellular and molecular
factors that enlighten the understanding of cancer biology and behavior and can potentially be targeted to
prevent and/or reduce the cancer burden in the UC Davis Comprehensive Cancer Center (UCDCCC)
catchment area and beyond. The Program brings together geneticists, molecular and cellular biologists,
biochemists, pharmacologists, pathologists, and clinicians to conduct high-impact basic science research with
the goal identifying and understanding the dysregulation of critical pathways that lead to the initiation,
progression, metastasis, and recurrence of cancer. The Program has three Specific Aims that encompass the
breadth and depth of Program members. Aim 1 is to define mechanisms to maintain genome stability. Aim 2 is
to Interrogate key signal transduction and hormone receptor pathways. Aim 3 is to understand the role of
energetics and metabolism in cancer. Kermit Carraway, PhD (cancer biochemist and molecular biologist) and
Wolf-Dietrich Heyer, PhD (cancer geneticists and chromosome biologist) are co-leaders for MOP. The
Program’s research portfolio spans the basic cancer research continuum, from genetics, genomics,
chromosome biology, and biochemistry, to metabolism, energetics, and molecular and cellular biology. MOP
has 33 full members from four schools/colleges and 11 departments at UC Davis. MOP’s total cancer relevant
funding is $6.4M annual direct cost, including $6.3M is peer-reviewed and $1.8M in NCI funding. The total
number of publications is 369 of which 15% are intra-programmatic, 32% inter-programmatic, 38% multi-
institutional, and 30% published in high impact journals. MOP has instituted Program-wide strategies to
maintain a strong total funding base. To increase cancer relevant funding, the UCDCCC provides abundant
transdisciplinary fora and discretionary funding support to the MOP, providing its leadership the ability to
support pilot projects that will result in high-impact team science cancer research.

## Key facts

- **NIH application ID:** 10492546
- **Project number:** 5P30CA093373-20
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Wolf-Dietrich Heyer
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $107,810
- **Award type:** 5
- **Project period:** 2002-07-01 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10492546

## Citation

> US National Institutes of Health, RePORTER application 10492546, Molecular Oncology Program (5P30CA093373-20). Retrieved via AI Analytics 2026-06-11 from https://api.ai-analytics.org/grant/nih/10492546. Licensed CC0.

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