# Administrative Core

> **NIH NIH U19** · MAYO CLINIC ROCHESTER · 2022 · $127,356

## Abstract

PROJECT DESCRIPTION/ABSTRACT – ADMINISTRATIVE CORE
 The goal for our Center of Innovation for Brain Tumor Therapeutics is to develop effective novel therapeutic
strategies for glioblastoma (GBM). The primary strategy pursued is focused on optimal integration of novel
DNA damage response (DDR) inhibitors with standard-of-care genotoxic agents to potentiate the effects of
proven therapies. The overarching framework applied to this problem incorporates fundamental tumor biology
of DNA damage signaling integrated with cutting edge pharmacokinetic (PK) and pharmacodynamic (PD)
evaluation of spatial drug distribution and effect and systems analysis of drug perturbation of signaling
networks to develop optimized therapeutic strategies. Pre-clinical studies will be performed using a large,
highly characterized panel of patient-derived xenograft (PDX) models, and results from these studies will be
used to guide development of pilot clinical trials in both Projects. The Therapy Evaluation Core will support the
execution of these animal and human studies, and the Pharmacology Core will support the PK and PD
analysis of specimens obtained in these animal and human studies. The highly integrated analyses planned
across the two Projects and two Cores will be organized and facilitated by the Administrative Core. The
Administrative Core also will facilitate the connection of the Center team with the broader Glioma Therapeutics
Network. Functions for the Administrative Core can be broadly characterized as five specific aims:
Aim 1: Provide overall leadership for the Center
Aim 2: Guide scientific planning and evaluation of Projects and Cores
Aim 3: Foster integration and communication of Project and Core teams
Aim 4: Administrative management of the Center
Aim 5: Facilitate interactions with the Glioma Therapeutics Network and external collaborators

## Key facts

- **NIH application ID:** 10492764
- **Project number:** 5U19CA264362-02
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** Jann N. Sarkaria
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $127,356
- **Award type:** 5
- **Project period:** 2021-09-01 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10492764

## Citation

> US National Institutes of Health, RePORTER application 10492764, Administrative Core (5U19CA264362-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10492764. Licensed CC0.

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