# Core B- Biospecimen Core

> **NIH NIH P50** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 · $173,860

## Abstract

Core B – Biospecimen Core: Summary/Abstract:
The projects of this LMS SPORE will use leiomyosarcoma (LMS) biospecimens for translational research. A key
function of this Core will be ensuring the accuracy of diagnosis of LMS. To that end, Jason Hornick, MD, PhD,
an expert sarcoma pathologist, will Co-Direct the Biospecimen Core along with Nilsa Ramirez, MD, an expert in
biospecimen repositories and banking. The functions of the Biospecimen Core will include pathology review,
biospecimen procurement from the institutions participating in the LMS SPORE clinical studies, basic and
specialized processing, management of biospecimen-related data, and distribution of biospecimens and data to
project investigators. Biospecimens collected for this LMS SPORE will be prioritized to distribute to the LMS
SPORE investigators for the defined projects. After the needs of the planned research have been addressed,
residual banked biospecimens can be distributed to other investigators using existing mechanisms established
by the Administrative Core/MPI of this LMS SPORE.
The Biospecimen Core will provide the latest biorepository-based technological innovations and best practices,
resulting in constant improvements in operational capabilities, investigator access to biospecimens, and the
stewardship of these precious resources. Dr. Nilsa Ramirez, who has extensive experience in the management
of biospecimen quality control, processing, and banking, will oversee all activities of the Biospecimen Core and
will provide guidance to the Project leaders regarding biospecimen best practices. Dr. Hornick will oversee the
review of pathology and histology assessments to confirm diagnosis of all cases of LMS and will be the arbiter
in case of discrepancy in the diagnosis.
The Biospecimen Core will work closely with the Administrative Core and the project leadership to ensure the
success of the planned research. The collaborative nature of this LMS SPORE is necessary for the study of this
subtype of rare malignancies, where only multi-institutional cooperation can facilitate the acquisition of sufficient
biospecimen resources vital to make progress. The biospecimens banked in the Biospecimen Core will provide
an essential resource for the LMS SPORE team as well as future investigators.

## Key facts

- **NIH application ID:** 10493632
- **Project number:** 1P50CA272170-01
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** NILSA DEL CARMEN RAMIREZ MILAN
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $173,860
- **Award type:** 1
- **Project period:** 2022-09-16 → 2027-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10493632

## Citation

> US National Institutes of Health, RePORTER application 10493632, Core B- Biospecimen Core (1P50CA272170-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10493632. Licensed CC0.

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