PROJECT SUMMARY/ABSTRACT The overall goal of the Administrative Core (AC) is to provide a structure and set of activities that integrates the science and scientists of the Integrative Omics Center for Accelerating Neurobiological Understanding of Opioid Addiction (ICAN) to facilitate breakthrough discoveries in the biological drivers of opioid addiction (OA). The diversity of scientists, omics data, cohorts, species, and analyses are substantial strengths of ICAN. That diversity is also a challenge. We will systematically meet this challenge through frequent cross-ICAN interaction, shared milestone setting and evaluation, use of centralized computing and protocol development in the Synergy Core (SynC), and leveraging collaboration technology. The AC, in conjunction with the SynC, will create synergy from diversity to collectively achieve ICAN aims and enrich the community. The AC has the following specific aims: Aim 1. Establish the Center Steering Committee as a conduit for cross-ICAN communication and governance. Aim 2. Establish the External Advisory Board as an active connection to external expertise and consortia to enhance the science and impact of ICAN. Aim 3. Set annual milestones and evaluate performance for ICAN, as well as for each Project and Core. Aim 4. Leverage sharing technology to enhance investigator interaction and documentation. Aim 5. Provide education and outreach to the community, facilitating ICAN’s role as a national resource.