# The Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE)

> **NIH NIH P50** · JOHNS HOPKINS UNIVERSITY · 2022 · $4,081,586

## Abstract

OVERALL
PROJECT SUMMARY
The overarching goal of the Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE) is to test the
effectiveness of comprehensive, integrated, and multi-level evidence-based strategies for improving
cardiometabolic health outcomes among socially disadvantaged populations in Maryland, using community-
based participatory research and patient-centered outcomes research principles, and translate them into
clinical and public health practice and policy. We will leverage the existing infrastructure of the Johns Hopkins
Center for Health Equity, which has applied a comprehensive approach to health equity for over 10 years, a
partnership with the University of Maryland Baltimore, and collaborations with Morgan State University and
other institutions in the region. MACCHE will include 3 separate, but related intervention studies addressing
disparities in cardiometabolic disease; 3 integrated cores (Administrative, Investigator Development, and
Community Engagement); an Executive Committee; and a Community Advisory Board. Study 1 is a
randomized trial comparing the effectiveness of an evidence-based pregnancy/postpartum health
coaching/home visiting intervention to usual home visiting services in reducing postpartum weight retention
among Black and Latinx women at high risk for cardiometabolic health disparities; Study 2 is a randomized trial
examining the effectiveness of a multi-level intervention of problem-solving training, community health worker
(CHW) support and partnership with community facilities for enhancing cardiorespiratory fitness in adults with
low socioeconomic status, diabetes, obesity and asymptomatic cardiac dysfunction; and Study 3 is a cluster-
randomized trial testing the effectiveness of a multi-level intervention linking self-monitored blood pressure
(BP) with telemonitoring, team-based care with pharmacists and CHWs, and provider-level interventions
compared to enhanced usual care, for improving BP control among socially disadvantaged adults with
uncontrolled hypertension plus diabetes or chronic kidney disease. The Administrative Core will carry out the
overall administration of the grant, providing infrastructure and support for data harmonization, management
and analysis, patient recruitment and retention, and intervention adaptation and implementation. The
Investigator Development Core will establish a pilot project program for early-stage investigators and create a
mentoring network and community for pilot project awardees, to support innovative research related to chronic
disease disparities. The Community Engagement Core will implement a shared governance structure to
reinforce stakeholder leadership and ownership; advance, facilitate, and evaluate MACCHE’s community-
engaged research and investigator development initiatives; and employ community-centered strategies to
translate, disseminate, and sustain MACCHE initiatives. The MACCHE will advance the science of
cardiometabolic disease dispar...

## Key facts

- **NIH application ID:** 10494167
- **Project number:** 5P50MD017348-02
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** LISA A COOPER
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $4,081,586
- **Award type:** 5
- **Project period:** 2021-09-24 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10494167

## Citation

> US National Institutes of Health, RePORTER application 10494167, The Mid-Atlantic Center for Cardiometabolic Health Equity (MACCHE) (5P50MD017348-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10494167. Licensed CC0.

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